RESUMEN
A simple eco-friendly method has been developed for detection of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms. Both conventional system and microwave assisted procedures are used for the development of color. The blue coloured complex is measured spectrophotometrically at 750nm. Peak shift in FT-IR spectra also indicated the formation of complex
The reaction obeys Beer's law over the concentration range of 50-250ng/ml of hydroxyzine dihydrochloride
The precision value [infra-day and inter-day RSD] for the drug is not greater than 0.79% and recoveries were found to be in range of 99.01-99.99%
The designed method is applicable for periodic determination of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms
RESUMEN
A simple, fast and cost effective method for determination of Aceclofenac in pure and tablet formulations has been developed and validated. The method is based on formation of stable blue coloured complex [lambda[max] = 740nm] of Aceclofenac with ammonium molybdate in presence of sulfuric acid under microwave irradiation for 5min. Peak shift in FT-IR spectra also indicated the formation of complex. Measurement of absorbance was carried out at lambda[max] = 740nm. The reaction obeys Beer's law over the concentration range of 50-250 micro g/ml of Aceclofenac. The RSD [intra-day and inter-day precision] for the drug is not greater than 0.95% and recoveries were found to be in range of 99.01-99.99%. The proposed method can be used successfully for routine analysis of Aceclofenac in pure and tablet formulations