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AbstractIntroduction Aging is associated with a chronic low-grade inflammatory process characterized by an increased production of inflammatory mediators. These elevated levels are predictors for muscle function (sarcopenia) and deterioration of physical performance in the elderly.Objective To investigate the correlation between sarcopenia, functional capacity, and interleukin-6 levels.Materials and methods This cross-sectional study assessed a convenience sample of elderly individuals (n = 130) using a handgrip dynamometer (JAMAR™), and the functional capacity test was performed by sitting and standing. Interleukin-6 levels were determined using high sensitivity ELISA kits. Spearman correlation coefficient was used to assess the correlation between these variables, at a significance level (α) of 0.05.Results There was significant inverse correlation between strength and function (rS = -0.273, p = 0.002) such that elderly individuals with lower peak force took longer to perform the sit-to-stand test, in contrast with the relationship between plasma interleukin-6 levels and strength (rS = -0.043, p = 0.624) or functionality (rS = -0.060, p = 0.501).Conclusion The outcome measures analyzed could predict the decline in muscle strength and functional capacity, and may be indicative of sarcopenia in elderly individuals. There was no correlation between the interleukin-6 levels and the grip strength and functional capacity of the sample investigated.
ResumoIntrodução O envelhecimento está relacionado a uma ativação crônica sublimiar do processo inflamatório, com aumento da produção de mediadores inflamatórios, cujos níveis elevados são preditores do declínio da função muscular (sarcopenia) e capacidade funcional na população idosa.Objetivo Verificar a correlação entre sarcopenia, capacidade funcional e interleucina-6.Materiais e métodos : Estudo transversal, amostra de conveniência de idosas da comunidade (n = 130), em que se avaliou a força de preensão manual com dinamômetro de JAMAR®, e a capacidade funcional pelo teste de sentar e levantar da cadeira cinco vezes. A interleucina-6 foi analisada por meio de kits de alta sensibilidade, pelo método de ELISA. Utilizou-se o coeficiente de Spearman para verificar a correlação entre as variáveis, considerando o nível de significância (α) de 0,05.Resultados Houve correlação significativa e inversa entre a força manual e o teste funcional (rS = -0,273; p = 0,002), ou seja, idosas com menores picos de força apresentaram pior desempenho no teste de sentar e levantar. Não foi observada correlação entre as demais variáveis: índices plasmáticos de interleucina-6 e força (rS =-0,043; p = 0,624) e funcionalidade (rS = -0,060; p = 0,501).Conclusão As medidas de desfechos analisadas conseguiram rastrear a diminuição da força muscular e da capacidade funcional, podendo ser indicativas de sarcopenia em idosas. Os níveis de interleucina-6 não se correlacionaram com a força de preensão manual e com a capacidade funcional na amostra avaliada.
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Background: Low back pain (LBP) and urinary incontinence (UI) are highly prevalent among elderly individuals. In young adults, changes in trunk muscle recruitment, as assessed via ultrasound imaging, may be associated with lumbar spine stability. Objective: To assess the associations between LBP, UI, and the pattern of transversus abdominis (TrA), internal (IO), and external oblique (EO) muscle recruitment in the elderly as evaluated by ultrasound imaging. Method: Fifty-four elderly individuals (mean age: 72±5.2 years) who complained of LBP and/or UI as assessed by the McGill Pain Questionnaire, Incontinence Questionnaire-Short Form, and ultrasound imaging were included in the study. The statistical analysis comprised a multiple linear regression model, and a p-value <0.05 was considered significant. Results: The regression models for the TrA, IO, and EO muscle thickness levels explained 2.0% (R2=0.02; F=0.47; p=0.628), 10.6% (R2=0.106; F=3.03; p=0.057), and 10.1% (R2=0.101; F=2.70; p=0.077) of the variability, respectively. None of the regression models developed for the abdominal muscles exhibited statistical significance. A significant and negative association (p=0.018; β=-0.0343) was observed only between UI and IO recruitment. Conclusion: These results suggest that age-related factors may have interfered with the findings of the study, thus emphasizing the need to perform ultrasound imaging-based studies to measure abdominal muscle recruitment in the elderly. .