RESUMEN
Objective: To determine the remission rate in adolescent and young adult [AYA] patients with acute lymphoblastic leukemia [ALL]
Study Design: Descriptive study
Place and Duration of Study: Department of Oncology, Jinnah Postgraduate Medical Centre [JPMC], Karachi from January, 2016 to March, 2017
Methodology: Adolescent and young adult [AYA] patients aged 15-39 years, newly diagnosed with acute lymphoblastic leukemia from January, 2016 to March, 2017. Diagnosis was confirmed by bone marrow trephine biopsy and immunophenotyping. All the patients were treated with daunorubicin, vincristine, prednisone, and L-asparaginase in the induction phase. The response evaluation was done on day 35 of the induction phase and the remission rate was assessed by the bone marrow examination
Results: Of the total 50 AYA patients diagnosed with ALL, 41 patients could complete induction phase and 9 patients died during the first week of induction, therefore excluded from the study. Forty [97.8%] patients were <35years of age, 28 [68.3%] were male, of female 10 [24.4%] were housewives, 33 [80.5%] patients belonged to Sindh, 28 [68.3%] presented with fever and body ache, 17 [41.5%] patients had precursor B cell type ALL, with 7 [17.1%] patients had hemoglobin of <7 g/dL,11 [26.8%] patients had white cell count of >30x109/L, platelet count of <20x103/µL in 6 [14.6%] patients and complete morphological remission was reported in 29 [70.7%] patients
Conclusion: The remission induction rate was 70.7% in the adolescents and young adults with acute lymphoblastic leukemia at the study centre
RESUMEN
Dermatofibrosarcoma protuberans [DFSP] is a rare malignant neoplasm of skin, subcutaneous tissue and dermis, with more potential of local infiltration, appears most frequently on the trunk, followed by extremities, head, neck, and extremely rare in breast. It often occurs in young adults and middle-aged adults. The standard of treatment for this disease is local surgical excision with 2-3 cm wide margins. We present a case of 49-year lady with right breast well-circumscribed, firm, tender, mobile, and progressive lump that was benign-looking, on physical examination as well as on mammography. She underwent local surgical resection and diagnosed as DFSP on microscopic and immunohistochemical analysis with positive deep margin. She was referred for further multidisciplinary management. Case was discussed in tumour board meeting and planned for re-resection of involved deep margin. After re-resection, she has remained disease-free for last 3 years without any evidence of local or distant recurrence. In this case report, the importance of surgical resection with adequate margins, is highlighted and long term follow-up by physical examination and ultrasound for any local recurrence of DFSP in breast