RESUMEN
A glucosidase inhibition assay has been used to evaluate extracts from higher plants. An enzyme inhibition of fifty percent or more correlated with the observed cytotoxicity of the extracts
Asunto(s)
beta-Glucosidasa/antagonistas & inhibidores , Extractos Vegetales/farmacología , Evaluación Preclínica de Medicamentos/métodos , Antivirales/farmacología , Muerte Celular/efectos de los fármacos , VIH/efectos de los fármacos , Linfocitos/efectos de los fármacos , Extractos Vegetales/toxicidad , Puerto RicoRESUMEN
Extracts from higher plants were evaluated for inhibitory activity against avian myeloblastosis virus reverse transcriptase. The assay may serve as a useful prescreen for potential anti-HIV bioactives
Asunto(s)
Antivirales/farmacología , Extractos Vegetales/farmacología , ADN Polimerasa Dirigida por ARN/antagonistas & inhibidores , Evaluación Preclínica de Medicamentos/métodos , VIH/efectos de los fármacos , Puerto Rico , Virus de la Mieloblastosis Aviar/enzimologíaRESUMEN
Four bacteria-derived immunopotentiators were tested for their protective effect on a P-388 mouse lymphocytic leukemia model. The microbial test products were prepared from the following bacterial strains: ATCC 35983 Staphylococcus epidermidis isolated from a patient with IV catheter; ATCC 31874, a patented strain listed as Staphylococcus epidermidis isolated from the urine of a cancer patient; ATCC 25615 Staphylococcus hominis obtained from a child with lymphocytic leukemia, and ATCC 25614 Staphylococcus warneri, an isolate from a patient with adenocarcinoma of the breast. A limited degree of protection and prolongation in survival time was observed in the animal group treated with the bacterial strain ATCC 31874