Synthesis and in-vitro Anti Tumor Activity of Some Novel 2, 3-Disubstituted Quinazolin 4(3H)-one Derivatives.

A series of 4-[2-(4-chlorobenzyl)-4-oxoquinazolin-3(4H)-yl)benzoyl] derivatives were synthesized. The synthesized compounds were characterized by IR, NMR and Mass spectral data and were screened for their anti cancer activity.The in vitro anticancer studies were performed on 4 selected compounds using MTT assay against HeLa cell line (NCCS).The synthesized 2, 3-disubstituted-3H-Quinazolin-4-one derivatives exhibited significant Anti oxidant and anti tumor activities.