Histocompatibility antigens and insulin-dependent diabetes: a study of 20 brazilian families

The relationship between histocompatibility antigens (HLA) and insulin-dependent diabetes was examined. The relative frequency of HLA and the relative risk were determined for 20 families containing 82 individuals, 23 of whom hda insulin-dependent diabetes. The control group contained 102 individuals. 2 The B8, B13, and B15 antigens had the highest relative frequency in the group of diabetic patients, whereas B5, B7 and B12 were lowest. A high relative frequency of histocompatibility antigens was found not only in the diabetic patients, but also in their parents and siblings. There was a predominance of A2B8, A2B15, and A9B15 haplotypes in the diabetic population. The diabetic siblings hda identical haplotypes. 3. These data support previous reports suggesting gwenetic linkage between susceptibility to diabetes and the histocompatibility antigen systen

Antigenos de histocompatibilidade e diabetes insulino-dependente: estudo em familias. / Histocompatibility antigens and insulin-dependent diabetes: a study in families

Foram estudadas 20 familias de individuos com diabetes insulino-dependente, em um total de 23 pacientes, visando a determinar a frequencia dos antigenos de historia compatibilidade e calculo do risco relativo. Foi observada maior frequencia dos antigenos B8, B13, e B15 e menor de B5, B7, e B12, na populacao diabetica. Para os antigenos nos quais se observou frequencia superior nos diabeticos, o fenomeno tambem ocorreu entre pais e irmaos. Tal situacao, entretanto, nao se repetiu quando a frequencia era mais baixa entre os diabeticos. Na populacao diabetica, houve predominancia dos haplotipos A2B8, A2B15, A9B13, e A9B15. Todos os irmaos diabeticos apresentavam haplotipos identicos, o que sugere a provavel segregacao de genes de suscetibilidade a doenca com o sistema HLA