RESUMEN
Delayed type hypersensitivity skin testing to tetanus toxoid was performed in 498 healthy Thai children. The subjects were 230 males and 268 females. The ages at testing were 2, 4, 6, 9, 15, 18 and 48 months and the number of subjects were 98, 94, 82, 77, 43, 70 and 34, respectively. The study was performed by intradermal injection of 0.1 ml. of tetanus toxoid (20 Lf/ml) 0.1 ml at the volar surface of left forearm. An indurations of 5 mm. or greater at 72 hours was considered a positive result. The positive result in each group was 7.14, 30.85, 76.82, 98.7, 90.7, 97.14 and 94.12 percent respectively. The mean induration size in each group was 2.16, 3.74, 6.46, 9.79, 10.42, 9.07 and 9.76 mm., respectively. The results of the study showed no difference between the sexes. Positive skin tests to tetanus toxoid were correlated to the number of previous DPT immunizations. No significant adverse reaction was found. These results indicate that tetanus toxoid skin testing is safe and yields highly positive results in children who have been immunized with tetanus toxoid. It should be used as an antigen for delayed type hypersensitivity skin testing as PPD, mumps, monilia, trichophyton and streptokinase-streptodornase.
RESUMEN
The relationship of theophylline concentration in serum and saliva was studied in 10 Thai asthmatic children receiving “Elixir Quibron” and Tablet Aminophylline orally in a cross over design. There was an excellent linear relationship between theophylline concentration in serum and saliva regardless of dosage forms. Proportionality factor that relates saliva to serum concentration obtained in this study was 1.60. Serum Theophylline concentration can be estimated by analysis of saliva concentration multiplied by 1.60. These observations suggest that determination of theophylline concentration in saliva is an effective, convenient, noninvasive, and painless method for routine indirect monitoring of serum theophylline concentration in Thai asthmatic children.