Malondialdehyde-modified LDL IgG antibody levels and indices of cardiac function in valvular heart and coronary artery disease patients

To compare the changes in anti-malondialde-hyde-modified low-density lipoprotein [MDA-LDL] IgG levels among patients undergoing off-pump and on-pump coronary artery bypass grafting [CABG] or valvuloplasty. A total of 38, 39 and 34 patients who underwent off-pump CABG, on-pump CABG and valvuloplasty, respectively, were enrolled in this study. Serum anti-MDA-LDL IgG values were measured 24 h before and after the operative procedures and at discharge. Echocardiogra-phy was also done before surgery and before discharge. The results were compared with values from 50 healthy controls. In all patients, a reduction in antibody titers was observed post-operatively. However, the decrease was significant only in the off-pump CABG - before surgery: 42.33 [25.83-58.51], after surgery: 30.86 [16.36-51.33] and at discharge: 10.96 [6.82-23.57; p = 0.027]. There was a significant positive association between anti-MDA-LDL IgG levels and ejection fraction [r = 0.248, p = 0.036] and a negative association with E/E', a marker of pulmonary capillary wedge pressure, in the coronary patients [r = -0.345, p = 0.012], but no significant associations were found in patients with valvular heart disease. Serum anti-MDA-LDL IgG levels were associated with cardiac function indices in coronary patients undergoing CABG

[ effect of cardiopulmonary pump on hearing loss after cardiopulmonary bypass graft]

Coronary artery bypass graft is one of the most common surgeries in hospitals. Almost 50% of patients have complications. One of these complications is hearing loss. Coronary artery bypasses grafting patients having inclusion criteria participated. One day before surgery, One day after surgery and if patients had hearing loss, the nest week otoacoustic emission test was done. Patients were divided in to two groups: on pump and off pump bypass surgeries. Hearing loss occurred in 12%. Hearing loss in on-pump patients was 14.3% and in off-pump was 6/7% [p=0.09]. The relation of preoperative OAE test and final OAE was tested and it was significant [p<0.005]. In male patients, hearing loss in on-pump operation was 18/6% [p=0.002] and in females in on-pump operation was 7/4% and in off-pump operation was 18.2% [p=0.1]. Hearing loss occurred in 4/2% in 1500, 2000 HZ; 12./5% in 2500, 3000 HZ and 83/3% in 3500, 4000 HZ. It after coronary artery bypass graft is rather Frequents [12%] and is more common in on-pump surgery, and occurs in high frequency, hearing loss is more common in male patients