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Background@#Pain, edema, and trismus are predictable sequelae for surgical extraction of impacted mandibular third molars (M3M). The present study aimed to compare the anti-phlogistic potential of bromelain and aceclofenac in the reduction of post-surgical sequalae in the extraction of impacted M3M.Method: A randomized controlled, triple-blinded clinical study included 72 patients scheduled for surgical removal of impacted M3M under local anesthesia. Randomization was performed and subjects were equally allocated to groups A (control) and B (study), who intended to receive aceclofenac and bromelain, respectively. The primary outcome variables were pain, edema, and trismus evaluated on postoperative days 2 and 7 and compared with baseline values. The secondary variables evaluated were the quantity of rescue analgesics required and the frequency of adverse effects in both groups for 7 postoperative (PO) days. Data were analyzed with a level of significance of P 0.05). @*Conclusion@#The present study showed that the efficacy of bromelain was comparable to that of aceclofenac in reducing inflammatory complications following surgical removal of impacted M3M. Bromelain can be considered a safe and potent alternative to routinely used aceclofenac when addressing inflammatory outcomes after surgery.
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Aims: Injection snoreplasty was recently introduced as a safe, effective, and minimally invasive treatment for primary snoring. We assess the effectiveness of the treatment in our patients. Study Design: It was a prospective, non-randomised study on 54 patients with primary snoring. Place and Duration of Study: Study was done in the department of otolaryngology &head neck surgery at PGIMER, Chandigarh, India over 7 years between January 2004 and December 2010. Methodology: Patients were questioned about their symptoms; a detailed clinical and radiological examination was done in all patients. All the causes of snoring were ruled out. 1-3% sodium tetradecyl sulphate (STS) injection was administered in all patients in 1-3 sittings. Patients were assessed after 1, 3 and 6 months and their improvement was noted Results: There were 47 males and 7 females enrolled in our study with mean age as 47.6 years. The mean duration of snoring was 76.1 months. The average BMI of patients was 28.11. All the patients except 4 were initially injected 1% STS injection; the others were injected 3%. 11 patients were re-injected at 1 month and 4 had 2nd re-injection at 3 month follow up. The mean improvement in symptoms was 57.24%. The only side effect was pain which in majority of patients was mild. There was no correlation between BMI and percentage of improvement. Conclusion: Injection snoreplasty is a safe and cost effective treatment for primary snoring.
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STUDY DESIGN: Prospective case series. PURPOSE: To study the safety and feasibility of cotransplantation of bone marrow stem cells and autologous olfactory mucosa in chronic spinal cord injury. OVERVIEW OF LITERATURE: Stem cell therapies are a novel method in the attempt to restitute heavily damaged tissues. We discuss our experience with this modality in postspinal cord injury paraplegics. METHODS: The study includes 9 dorsal spine injury patients with American Spinal Injury Association (ASIA) Impairment Scale (AIS) A neurological impairment who underwent de-tethering of the spinal cord followed by cotransplantation with bone marrow stem cells and an olfactory mucosal graft. Participants were evaluated at the baseline and at 6 monthly intervals. Safety and tolerability were evaluated through the monitoring for adverse events and magnetic resonance imaging evaluation. Efficacy assessment was done through neurological and functional outcome measures. RESULTS: Surgery was tolerated well by all participants. No significant difference in the ASIA score was observed, although differences in the Functional Independence Measure and Modified Ashworth Scale were statistically significant. No significant complication was observed in any of our patients, except for neurogenic pain in one participant. The follow-up magnetic resonance imaging evaluation revealed an increase in the length of myelomalacia in seven participants. CONCLUSIONS: The cotransplantation of bone marrow stem cells and olfactory mucosa is a safe, feasible and viable procedure in AIS A participants with thoracic level injuries, as assessed at the 24-month follow-up. No efficacy could be demonstrated. For application, further large-scale multicenter studies are needed.