Human parvovirus B19 in children with sickle cell disease; poking the spleen

Parvovirus is a known culprit of transient red cell aplasia [TRCA] in children with sickle cell disease [SCD]. Few reports have previously described the association between the virus and acute splenic sequestration crisis [ASSC] in the same patient. Here, we are shedding light on such a potentially serious combination by reporting two cases of siblings with SCD complicated with concurrent ASSC and TRCA and presenting a review of the relevant literature