RESUMEN
To assess the prevailing pathogens and their sensitivity pattern to antibiotics in our Neonatal Intensive Care Unit [NICV]. This was a descriptive study carried out from 1[st] July 2004 to 30[th] June 2005, at National Institute of Child Health, Karachi: All the neonates admitted into NICU with strong suspicion of neonatal sepsis were included in the study. A total of 687 cases with suspected sepsis were admitted and blood was sent for culture and sensitivity. Out of 687 cases, 319 [46.43%] were positive on blood culture. Frequent offenders were gram negative organisms 295 [92.48%]. Out of 295 gram -ve blood culture, Enterobacter was the most common pathogen [52.88%, n=I56], followed by Klebsiella [22.37%, n=66], Pseudomonas [21.0%, n=62], E.coli [2.0%, n=6], Citrobacater [1.35%, n=4] and Serratia. [0.33%, n=1]. Among grams +ve organisms [7.52% n=24] Staph aureus was the main causative organism [n=17] followed by Streptococcuspneumoniae [n=4] and streptococcus spp [n=3]. Multi-drug resistant gram -ve organisms are emerging as significant pathogens among cases of neonatal sepsis in our NICU
RESUMEN
This study was conducted at the Department of Paediatric Medicine at National Institute of Child Health [NICH], Karachi, from January, 2003 to December, 2003. Hundred children were admitted with Enteric fever and studied prospectively. These accounted for about 1% of the total admissions. Inclusion criteria was positive blood and / or bone marrow culture. Majority of patients [95] had blood culture positive for Salmonella typhi. Salmonella para-typhLA found in 3 cases and Salmonella para-typhi B in 2 cases only. Bone marrow culture was positive in 25% patients. Majority of the isolates were sensitive to all the primary and the 3rd generation cephalosporins. The patients were between the ages of 5-10 years. Male to female ratio was 2:1. Presenting symptoms were mainly fever, vague abdominal symptoms, anorexia, nausea, vomiting, diarrhoea, headache and cough. One patient presented with a picture of hepatic failure with favorable outcome. Two patients developed arthritis and one developed enteric perforation with fatal outcome