study of glutathione uric acid status in the nasal mucucosa of chronic sinusitis patients

There is an increasing interest in the concept that oxidant antioxidant imbalance plays a role in the pathogenesis of chronic inflammatory disorders of the respiratory tract. This study was planned to determine if patients with chronic sinusitis demonstrate altered levels of the tissue antioxidants glutathione and auric acid, compared to healthy control mucosa. Inflamed uncinate process mucosa samples were obtained from 50 patients with chronic sinusitis during functional endoscopic sinus surgery. Normal mucosal samples were collected from 20 healthy controls. The levels of tissue uric acid and glutathione were determined biochemically. The data [presented as mean +/- SD] showed a significant reduction of the reduced glutathione level [0.3 14 +/- 0.055 micro mol/g wet weight] [P<0.01], and uric acid level [2.057 +/- 0.155 mol/g wet weight] [P<0.05], compared with healthy controls [0.61 +/- 0.13 and 2.85 +/- 0.22 micro mol/g wet weight, respectively]. Also there was a positive significant correlation between the mean values of glutathione and uric acid in patient samples [r=0.316]. The presented data suggested that the observed decrease of tissue antioxidant may play a role in the impaired defense mechanism of nasal mucosa during the course of chronic sinusitis and that adjuvant antioxidant therapy may have a role in achieving better prognosis in the disease management

Pre-and post-operative intravenous ketoprofen administration for analgesia after tonsillectomy in adults

Various studies have shown that non-steroidal anti-inflammatory drugs are effective in reducing pain after different types of surgery. They decrease the need for opioids, thus reducing the risk of opioid related side effects. Our study was designed to evaluate the safety and efficacy of ketoprofen during tonsillectomy in 50 adult patients receiving standardized general anaesthesia. Twenty patients received intravenous ketoprofen 0.5 mg/kg at induction [Pre-ketoprofen group] and twenty patients after surgery [Post-ketoprofen group] and ten patients received normal saline [Placebo group], Nubain [nalbuphine HCI] was used for rescue analgesia. Patients in both ketoprofen groups experienced less pain than those in the placebo group. There was no difference between the study groups in the proportion of patients who were given nubain during the first 4 hours after surgery, but during the next 20 hours, all patients in placebo group [100%] received nubain compared with patients in the pre-ketoprofen group [70%] and the post-ketoprofen group [65%] [P<0.001]. Patients in the placebo group received significantly more nubain doses than patients in the two ketoprofen groups [P<0.001]. No post-operative bleeding in any patients in all groups. We conclude that pre-and post-operative 0.5 mg/kg intravenous ketoprofen is effective for analgesia after tonsillectomy in adults; without increasing the incidence of post-operative haemorrhage