Comparative study of effectiveness of different dihydro-artemisinin (Cotecxin)tablet regimens in uncomplicated falciparum malaria

Dihydroartemisinin, one of the artemisinin derivatives is getting into ferquent use for its lower price and higher efficacy.In this study 32 and 21patients with uncomplicated falciparum malaria were treated with dihydroartemisinin tablet produced as Cotecxin, 480 mg over 3 days and 480 mg over 7 days respectively. The initial cure rates in both treatment groups were 100

but 34.37

recurred in 3 day treatment group and 19.05

in 7 day treatment. The resistance was only at R1 level and the recrudescence rates in both groups were not significantky different (P=0.37). The paarasite clearance times PCTs were 29.1-+1 hours in 3 day treatment and 26.62-+ 12.77 hours in 7 day treatment. All patients in both groups were free of side effects. The results support the previous findings that shorter course of artemisinin derivatives brung higher recrudescence.

Efficacy of two different short coure regimens of artemether plus mefloquine in acute uncomplicated falciparum malaria

One of the factors affecting the compliance in chemotherapy i duration of therapy. It is sseen in treatment of malaria with quinine in which its long course and side effects limit the patient's compliance. In this study two different short courses of artemether mefloquine were deployed. 27 patients in Group 1 received oral artemether 320 mg stat dose followed by mefloquine 750 mg after 24hours. In Group 2,28 patietns received same dose of Artemether followed by mefloquine 750 mg and 500 mg after 24 and 30 hours. Short parasite clearance times were observed a 28.74 + or - 15.16 hours in Group land 35.82 + or - 23.62 hours in Group 2. The cure rates were 74.07 per cent in firt group and 92.86 per cent in the latter. (p=0.06.Firsher xact test) The short course brought no side effects.

Efficacy of two different short course regimens of artemether plus mefloquine in acute uncomplicated falciparum malaria

One of the factors affecting the compliance in chemotherapy is duration of therapy. It is seen in treatment of malaria with quinine in which its long course and side effects limit the patient's compliance. In this study two different short courses of artemether mefloquine were deployed. 27 patients in Group 1 received oral artemether 320 mg stat dose followed by mefloquine 750 mg after 24 hours. In Group 2, 28 patients received same dose of Artemether followed bymefloquine 750 mg and 500 mg after 24 and 30 hours. Short parasite clearance times were observed as 28.74 + or - 15.16 hours in Group 1 and 35.82 + or - 23.62 hours in Group 2. The cure rates were 74.07

in first group and 92.86

in the latter. (P=0.06. Firsher exact test) The short course brought no side effects.

Comparative study of effectiveness of different dihydroartemisinin (cotecxin) tablet regimens in uncomplicated falciparum malaria

Dihydroartemisinin, one of the artemisinin derivativesis getting into frequent use for its lower price and higher efficacy. In this study 32 and 21 patients eith uncomplicated falciparum malaria were treated with dihydroartemisinin tablet produced as Cotecxin, 480 mg over 3 days and 480 mg over 7 days respectively. The initial cure rates in both treatment groups were 100 per cent but 34.37 per cent recurred in 3 day treatment group and 19.05 per cent in 7 day treatment. The resistance was only at R1 level and the recrudescence rates in both groups were not significantly different (P=0.37). The parasite clearance times PCTs ere 29.1 + or - 1hours in 3 day treatment and 26.62 + or - 12.77 hours in 7 day treatment. All patients in both groups ere free of side effects. The results support the previous findings that shorter course of artemisinin derivatives bring higher recrudescence.