Evaluation studies of antimicrobial activity on the leaf extracts of Achyranthes aspera Linn

Disc diffusion method was employed to determine the effect of methanol, acetone and chloroform extracts of the dried leaves of Achyranthes aspera against Staphylococcus aureus, Streptococcus fecalis, Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The chloroform extract shown to exhibit maximum potency against E. coli and Pseudomonas aeruginosa. Methanol extract showed moderate potency against E. coli and Candida species. Acetone extract was less effective against most of the species used except Streptococcus fecalis. Among all the extracts tested, none of the extract was found to be effective against gram positive S. aureus and gram negative Proteus vulgaris

Antimicrobial activity of extracts and isolates of the leaves of Plumeria alba Linn.

Disc diffusion method was employed to determine the effect of methanol, chloroform and acetone extracts of the dried leaves of Plumeria alba Linn. [Apocyitaceac] against fungi [Candida albicans] and bacteria [Bacillus subtilis, Proteus vulgaris Staphylococcus aureus. Pseudomonas aeruginosa, Streptococcus fecalis, Escherichio coil, Staphylococcus albus and Klebsiella pneumoniae]. The methanol and acetone extracts exhibited a prominent antimicrobial activity. The methanolic and acetone extracts were further fractionated by column chromatography to yield 2 pure isolates. The methanol pure component-2 [MPC[2]-50% Ethyl acetate:Methanol] and Acetone pure component-2 [APC[2]-70% Acetone:Ethyl acetate] have shown significant activity against all organisms used except Klebsiella

Anti-microbial activity of extracts and isolates of leaves of acalypha canescana linn

The in vitro antibacterial activity of the extracts and isolates of Acalypha canescana [leaves] have been studied against bacteria [Bacillus subtilis, Staphlylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa] and fungi [Candida albicans]. The total acetone extract, total methanol extract, total chloroform extract, total benzene extract and the fractionated two isolates of acetone extract and benzene extract have shown significant activity against the organisms used, almost comparable with the standard drugs Ciprofloxacin and Clotrimazolc. This in vitro testing also resulted in activity guided isolation of four antibacterial and antifungal principles from the leaves

In vivo anti-tumour activity of Wrightia tomentosa in Ehrlich ascites carcinoma bearing mice

Anti-tumour activity of ethanolic extracts of leaf and bark of Wrightia tomentosa [Fam: Apocynaceae] in the mice transplanted with Ehrlich ascites carcinoma [EAC] were investigated. The EAC mice receiving 100 and 200 mg/kg ethanolic leaf and bark extract showed a dose dependent elevation in tumour-free survival and a highest number of survivors were observed at 200 mg/kg for leaf extract of ethanol. which was considered as an optimum dose for its neoplastic action. The Median survival time [MST] for this dose was approximately 44 days when compared with 23 days of non-drug treated controls. Statistical analysis also indicates that the leaf extract showed highly significant anti-tumour potency [p<0.00l] when compared with control