Spectrofluorimetric determination and kinetic study of ceftibuten

In this work, a simple and sensitive spectrofluorimetric method was developed to study ceftibuten degradation. It was also applied for the indirect determination of drug in bulk and pharmaceutical capsules. The procedure was based on the reaction of the degraded product with the fluorogenic reagent, fluorescamine. The proposed analytical method was optimized and validated. The detection limit was 0.1035 mug/ml. The activation energy for the degradation was 2.607 Kcal mol1

Kinetic study on the hydrolysis of erythromycin ethyi succinate

The stability of erythromycin ethyl succinate in prepared aqueous and pharmaceutical suspensions was investigated. The released free erythromycin base has been monitored by derivative spectrophotometric measurement of the yellow color formed after dilution with 9 N hydrochloric acid. The proposed analytical method has been optimized and validated. The activation energy for the hydrolysis of the ester in buffer [pH 7] was found to be 2.0839 Kcal./mole. In oral suspension for pediatric use, the ester was found to be stable for at least 15 days after reconstitution