[Cutaneous reactions of anticonvulsant drugs]

Cutaneous drug reaction is a common side effect of antiepileptic drugs and a frequent cause of treatment discontinuation. These reactions ranges can be a mild maculopapular rash to Stevens-Johnson Syndrome and toxic epidermal necrolysis. Among the traditional anticonvulsant drugs the aromatic compounds Phenytoin, Phenobarbital and carbamazepin have been associated with relatively higher incidences of cutaneous reactions which can hospitalized the patient. Some of the newer drugs also can induce this problem, especially lamotrigine. All records of patients who were hospitalized at hospitals related to Islamic Azad as well as Rasol Akram hospital with a diagnosis of cutaneous drug reaction to anticonvulsant therapy in 8 years period were reviewed. The most common culprit was phenytoin [32%] and the least common drug was lamotrigin [3%]. Cutaneous reaction to anticonvulsant drugs is common and sometimes may be life threatening which needs serious treatment options

No association between gadolinium-based contrast agents and development of nephrogenic systemic fibrosis: a case study

Nephrogenic systemic fibrosis [NSF], previously known as nephrogenic fibrosing dermopathy, is an emerging systemic fibrosing disorder that develops in the setting of renal insufficiency. Nephrogenic fibrosing dermopathy [NFD] is a fibrosing condition of the skin which shows an increased number of dendritic cells, fibroblasts and thickened collagen fibers resembling scleromyxedema. It is characterized by indurated plaques mainly on the extremities and the absence of paraproteinemia. Although the exact causes of NSF have not been established, evidence suggests an association between gadoliniumbased contrast agents and development of nephrogenic systemic fibrosis. We report a patient who was under dialysis and developed NSF but she never did MRI

[Efficacy of combined triple therapy [paramomycin ointment, cryotherapy and intralesionalglucantime] in comparison with intralesionalglucantime for the treatment of acute cutaneous leishmaniasis]

In spite of different methods of treatment, there is not a simple, safe and complete curative treatment for cutaneous Leishmaniasis[CL], yet. To compare the efficacy of intralesionalGlucantime injection alone, with the combined triple therapy of cryotherapy, paramomycin ointment and intralesionalGlucantime in the treatment of CL. 157 patients with CL were randomly allocated into 2 groups, 81 patients in group 1 were injected with intralesionalGlucantime[Twice a week up to healing to the lesions or maximum 6 weeks]. 76 patients in group 2 were treated with Paramomycin ointment [15% in 10% urea, twice a day], cryotherapy[Maximum 3 times 2 weeks] apart and injection of intralesionalGlucantime[Once a week], for the same period as group 1. After 6 weeks, complete cure rate in group 2 [89.5%] was significantly more than group 1 [70.4%][P < 0.05]. Our results indicating of more efficacy of the triple therapy is in accordance with the previous studies of combined cryotherapy and Paramomycin. It could be recommended as a better treatment modality for CL wherever possible