Ocular manisfestations in xeroderma pigmentosum; a series of 20 patients

To assess the various ocular manifestations in xeroderma pigmentosum seen at Eye and Dermatology Department of Chandka Medical College Hospital Larkana. Prospective study. This study was carried out at two Departments, i.e. at Departments of Dermatology and Ophthalmology of Chandka Medical College larkana from January 2013 to December 2014. Twenty cases were enrolled from outpatient of Eye and Skin Department, Chandka Medical College Hospital Larkana. Patients were subjected to detail history, complete eye and skin examination and relevant investigations. 20 patients, 12 [60%] males and 8 [40%] females with xeroderma pigmentosum in a gender ratio of 1.5: 1 were recruited. All patients had skin freckles and increased sensitivity to sun light. Photophobia and conjunctivitis was seen in 18 [90%] cases, keratitis and dry eyes was seen in 12 [60%] cases and 4 [20%] cases had malignancies of lids and conjunctiva proved on biopsy. Our cases belongs to larkana and sukkur division. The present study highlights the eye involvement in xeroderma pigmentosum and thereby early detection of eye disease prevent the malignancies and blindness

analysis of clinoepidemiological variables of psoriasis in a tertiary care hospital in Karachi, Pakistan

Psoriasis is a chronic inflammatory skin disease of unknown origin. Different factors might be influencing its course. The aim of our study was to observe and analyze different clinoepidemiological variables of psoriasis in patients reporting to a tertiary care hospital in Karachi. Prospective study This study was conducted at Jinnah Postgraduate Medical Centre, Karachi, Pakistan from January 2014 to December 2014. 200 patients [116 Males and 84 females] ages 18 and above with mild to severe psoriasis were selected and assessed on one occasion which included detailed history and examination. All data was documented on completion of study. A total 200 cases were studied. 90% had chronic plaque psoriasis. There was male preponderance with a male to female ratio of 1.38:1. Mean peak age of onset was 11-20 years of age and was earlier in females than males. More than two-third of patients had onset of psoriasis before or at 40 years of age. Familial occurrence was present in 38% of patients and 35% had first degree relative involvement. Psoriatic arthropathy was present in 35% of patients. 86.36% of the patients with arthropathy had onset of psoriasis before 40 years of age. 21% of patients reported worsening of their psoriasis with sun. 32% of the patients in this study were smokers and most of them were males. The findings of this study done in Karachi, Pakistan correlates with previous hospital-based studies done in different parts of the world

Comparing the quality of life by using two therapeutic approaches [10% sulphur ointment and 5% permethrin cream] in scabies patients

To compare the quality of life by using two therapeutic approaches [10% sulphur ointment and 5%permethrin cream] in patients with scabies. Retrospective / comparative study. This study was conducted in Basic Medical Science Institute and Dermatology Department of Jinnah Postgraduate Medical Centre in Karachi from 1[st] Dec 2010 to 30[th] May 2011. This study sample consisted of 130 [4 dropped out] clinically diagnosed cases of scabies divided into two groups; A and B. Each group was further subdivided into three age groups. Group A was asked to apply 5% permethrin cream on day 0 and to be repeated after 15 days and GroupB treated with 10% sulphur ointment for three consecutive nights and repeated on day15. Data was gathered by a questionnaire. Patients follow up was done on days 3, 15 and 30 and quality of life was determined on day 0 and 30 by using Dermatological Life Quality Index. Quality of life was found to be low in scabies patients and treatment with 10% Sulphur ointment and 5% permethrin not only improved clinical symptoms but also their quality of life significantly. Scabies affects quality of life because of severe itching and lack of sleep and proper topical therapy significantly improves clinical symptoms and quality of life

Efficacy and safety of glucantime for cutaneous leishmaniasis - eight years experience at a tertiary care hospital of Karachi

To observe the efficacy and adverse effect profile of Glucantime in treatment of cutanous leishmaniasis. Cross sectional study. This study was conducted in Dermatology Department, JPMC Karachi from Jan 2007 to Jan 2015. 252 patients of CL, diagnosed clinically and confirmed parasitologically were treated with injection glucantime. After taking history and physical examination, baseline complete blood count ,Liver function tests, Renal function tests and ECG were performed. 76 patients were treated with intralesional injection and 156 patients were treated with intramuscular Glucantime. Treatment response was observed and adverse effects were noted. The data was recorded and analysed on SPSS version 16. Mean +/- SD was calculated for continuous variables like age, duration of disease. Categorical values like gender, type, morphology, site of lesions efficacy and adverse effects were recorded as numbers and percentages. The mean age of I/L group was 31.4 +/- 11.6 and for I/M group. Efficacy of Intramuscular Glucantime was76.3% in intralesional group and 86.9%in intramuscular group. Adverse effects were seen in 25 % of intralesional and 26.9 % of intramuscular group. Glucantime is effective and well tolerated drug in Old world CL both by intramuscular or intralesional route