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Objective To investigate the effect of different treatment methods on the survival of patients with stage Ⅳ differentiated thyroid cancer (DTC).Methods From January 2013 to June 2015,90 patients with stage Ⅳ DTC in the Second Hospital of Shanxi Medical University were randomly divided into three groups according to the digital table,A,B and C group,with 30 cases in each group.The patients in A group were treated with surgery combined with 131 I,and the patients in B group were treated with surgery combined with TSH inhibition,and the patients in C group were treated with operation combined with 131I + TSH inhibition.The therapeutic effect,postoperative quality of life score and short-term and long-term survival rate were evaluated.Results After treatment,the levels of Tg in A group [(25.06 ± 3.41)μg/L] and C group [(24.89 ± 3.27)μg/L] were significantly lower than that in B group [(45.46 ± 3.58) μg/L],and the levels of TSH in B group [(0.36 ± 0.26) mU/L] and C group [(0.36 ± 0.18)mU/L] were significantly lower than that in A group [(0.67 ± 0.31)mU/L] (t =3.624,3.337,3.289,3.667,all P ＜0.05).The success rates of nail clearance in A group and C group were 50.00％ (15/30) and 56.67％ (17/30),respectively,which were significantly higher than 33.33％ (10/30) in B group (x2 =3.475,4.967,all P ＜ 0.05).The postoperative quality of life (GQOL[-74) scores among the three groups had statistically significant differences (F =4.354,5.216,4.672,5.197,all P ＜ 0.05).The 1-year (80.00％),2-year (53.33％) and 3-year (33.33％) survival rates in C group were significantly higher than those in A group (43.33％,36.67％,20.00％) and B group (40.00％,33.33％,16.67％) (x2 =5.467,3.661,3.287,all P ＜0.05).Conclusion For patients with stage Ⅳ DTC,the combination of 131I + TSH inhibitory regimen and operation regimen can significantly improve the therapeutic effect,improve the quality of life and prolong the survival time.
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Objective@#To investigate the effect of different treatment methods on the survival of patients with stage IV differentiated thyroid cancer (DTC).@*Methods@#From January 2013 to June 2015, 90 patients with stage IV DTC in the Second Hospital of Shanxi Medical University were randomly divided into three groups according to the digital table, A, B and C group, with 30 cases in each group.The patients in A group were treated with surgery combined with 131I, and the patients in B group were treated with surgery combined with TSH inhibition, and the patients in C group were treated with operation combined with 131I + TSH inhibition.The therapeutic effect, postoperative quality of life score and short-term and long-term survival rate were evaluated.@*Results@#After treatment, the levels of Tg in A group [(25.06±3.41)μg/L] and C group [(24.89±3.27)μg/L] were significantly lower than that in B group [(45.46±3.58)μg/L], and the levels of TSH in B group [(0.36±0.26)mU/L] and C group [(0.36±0.18)mU/L] were significantly lower than that in A group [(0.67±0.31)mU/L] (t=3.624, 3.337, 3.289, 3.667, all P<0.05). The success rates of nail clearance in A group and C group were 50.00%(15/30) and 56.67%(17/30), respectively, which were significantly higher than 33.33% (10/30) in B group (χ2=3.475, 4.967, all P<0.05). The postoperative quality of life (GQOLI-74) scores among the three groups had statistically significant differences (F=4.354, 5.216, 4.672, 5.197, all P<0.05). The 1-year (80.00%), 2-year (53.33%) and 3-year (33.33%) survival rates in C group were significantly higher than those in A group (43.33%, 36.67%, 20.00%) and B group (40.00%, 33.33%, 16.67%) (χ2=5.467, 3.661, 3.287, all P<0.05).@*Conclusion@#For patients with stage IV DTC, the combination of 131I+ TSH inhibitory regimen and operation regimen can significantly improve the therapeutic effect, improve the quality of life and prolong the survival time.
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Objective To explore the correlation between quantitative value of joint bone scan by single photon emission computed tomography (SPECT) and serum bone metabolic markers in patients with active rheumatoid arthritis (RA).Method Clinical data of 60 newly diagnosed RA patients were retrospectively collected in Department of Rheumatology and Immunology from May 2013 to December 2014,including 28 cases with medical history less than 6 months and 32 from 6 months to 2 years.Serum Cterminal telopeptide of type Ⅰ collgen(CTX-Ⅰ)and N-terminal propeptide of type Ⅰ collagen(PINP) were tested by chemiluminesence.SPECT whole body bone and target joint scan before treatment was done.Thirty-nine healthy subjects as control group received ultrasound,electrocardiogram,X-ray,and whole body bone imaging examination.Quantitative values of joint imaging were calculated for the statistical analysis.Result Demographic data between RA group and control group were comparable (P ＞ 0.05),including sample,sex,age and BMI.The joint SPECT value,CTX-Ⅰ and PINP levels were all significantly higher than those of control group (P ＜ 0.01),which were 6.48 ± 1.98 versus 3.73 ± 1.t6;(0.66 ± 0.37) mg/L versus (0.58 ±0.21) mg/L;(46.35 ±28.15) mg/L versus (30.47 ± 13.75) mg/L respectively.Joint SPECT values had positive correlations with serum CTX-Ⅰ levels in all RA patients,as well as PINP in patients with disease duration 6mon-2years.And the according correlation coefficients were 0.513,0.495,0.402 (P ＜ 0.05).But SPECT value had no correlation with CTX-Ⅰ (P =0.081) in patients with disease duration less than 6 mon.The correlation coefficient was 0.336.Conclusion SPECT imaging quantitative values were positively correlated with serum bone metabolic parameters.Thus SPECT imaging alone or combined with bone markers are helpful in diagnosing active RA.
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Objective To investigate the clinical value of 99Tcm-MIBI SPECT-CT image fusion technology for diagnosing breast tumor and detecting axiiiary lymph node metastasis. Methods 99Tcm-MiBI breast and axillary lymph node planar and SPECT-CT imaging in 80 female breast tumor patients were done. All patients had pathological examination results after surgery as control. Results SPECT-CT fusion images sensitivity for breast cancer diagnosis, specificity and accuracy rates were 88.2 % (45/51), 93.1% (26/29) and 90 % (71/80). Planar imaging sensitivity, specificity and accuracy rate were 82.4 % (42/51), 79.3 %(23/29) and 81.3 %(65/80). SPECT-CT fusion images were higher than planar imaging (P <0.05). SPECT-CT fusion images sensitivity, specificity and accuracy for detecting axillary lymph node metastasis were 81.8 %(18/22), 89.7 % (26/29) and 86.3 % (44/51). Planar imaging sensitivity, specificity and accuracy were 77.2 % (17/22), 86.2 % (25/29) and 82.4 %(42/51). There was no significant difference between them (P0.05). Conclusion SPECT-CT image fusion technology in the diagnosis of breast cancer is better than planar imaging. SPECT-CT image fusion in detecting axillary lymph node metastasis of breast cancer is similar to planar imaging.
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Objective To evaluate salivary gland function in primary Sjgren′s syndrome (pSS) objectively,and highly sensitive and significant indicators were chosen by correlative analyses of parameters of salivary gland scintigraphy with the histopathologic grading of labial biopsy in pSS.Methods Salivary gland scintigraphy was preformed using 99m TcO - 4 in 78 patients with pSS and 20 normal controls.Functional parameters of the parotid (Par) glands were calculated.The results of pSS groups were compared with normal controls.All patients with pSS underwent labial biopsy after imaging and Spearman rank correlation test was used for scintigraphy functional parameters and histopathologic grading.Results ① The maximum accumulation ratio (MAR) of Par gland significantly decreased with histopathologic grading increase ( r = -0 649, P