RESUMEN
Objective:To investigate the effects of Traditional Chinese Medicine(TCM) syndrome factors on the analgesic efficacy of oxycodone after laparoscopic hysteromyomectomy.Methods:Two hundred female patients, of American Society of Anesthesiologists physical statusⅠorⅡ, aged 20-59 yr, with body mass index of 18-30 kg/m 2, scheduled for elective laparoscopic hysteromyomectomy under general anesthesia, were divided into 4 groups according to the TCM syndrome types: kidney deficiency and blood stasis type group (group A, n=65), damp-heat stagnation type group (group B, n=53), Qi stagnation and blood stasis type group (group C, n=43), and phlegm and dampness stagnation type group (group D, n=39). Postoperative pain was assessed using the numerical rating scale (NRS). When the NRS score≥4, oxycodone was slowly injected intravenously in a titrated manner until the NRS score<4 (loading dose). The patient-controlled intravenous analgesia solution contained oxycodone 100 mg in 100 ml of normal saline.The patient-controlled intravenous analgesia pump was set up to deliver a 1-ml bolus dose with a 10-min lockout interval and background infusion at a rate of 1 ml/h.The loading dose of oxycodone and consumption of oxycodone on 1st and 2nd days after operation were recorded. Results:Compared with A and C groups, the loading dose of oxycodone and consumption of oxycodone on 1st and 2nd days after operation were significantly increased in B and D groups ( P<0.05). There were no significant difference in the parameters mentioned above between group B and group D and between group A and group C ( P>0.05). Conclusion:The TCM syndrome factors can affect the analgesic efficacy of oxycodone after laparoscopic hysteromyomectomy, and the postoperative analgesic efficacy of oxycodone is weakened comparatively in the patients of damp-heat stagnation type and of phlegm and dampness stagnation type.