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1.
Indian J Exp Biol ; 1999 Sep; 37(9): 871-5
Artículo en Inglés | IMSEAR | ID: sea-62110

RESUMEN

Studies have been performed to assess the possibility of using small unilamellar liposomes as therapeutic carriers to the brain of hypertensive rats. Rats were made temporal hypertensive by the infusion of angiotensin II (AII; 15 micrograms in 1 ml) through their right common carotid artery. Another control group was infused with physiological saline. Free 125iodine-BSA (125I-BSA) and 125I-BSA encapsulated liposomes (average diameter approximately equal to 100 nm) were injected in the tail vein 2 min after the infusion of AII or saline. Plasma radioactivity was monitored at different times up to 15 min when the cerebral uptake of 125I-BSA was determined. While a little variation in plasma clearance pattern of liposomes in hypertensive and control group was noticed, the uptake by cerebral tissues was markedly higher in hypertensive group. Analysis of pharmacokinetic parameters in relation to cerebral uptake indicated AII induced a short term opening of the blood-brain barrier (BBB) resulting in an increased cerebral uptake. Positively charged liposomes was found to be most effective in hypertensive state.


Asunto(s)
Angiotensina II/farmacocinética , Animales , Área Bajo la Curva , Barrera Hematoencefálica , Encéfalo/efectos de los fármacos , Modelos Animales de Enfermedad , Portadores de Fármacos , Hipertensión/tratamiento farmacológico , Liposomas , Ratas
2.
Indian J Biochem Biophys ; 1999 Aug; 36(4): 248-51
Artículo en Inglés | IMSEAR | ID: sea-28085

RESUMEN

The leishmanicidal property of piperine intercalated in liposomes and in mannose-coated liposomes was tested in experimental visceral leishmaniasis in hamsters. Mannose-coated liposomal piperine eliminated intracellular amastigotes of Leishmania donovani in splenic macrophages much more efficiently than did the liposomal piperine or free piperine. At a dose equivalent to 6 mg/kg body wt every 4th day for a total of 4 doses in 12 days, the mannose-coated liposomal piperine was found to reduce spleen parasite load to the extent of 90% in comparison to that achieved by liposomal piperine (77%) or free piperine (29%). Histological examination of spleen and liver function tests showed that the toxicity of piperine was reduced when mannosylated liposomal piperine was administered.


Asunto(s)
Alcaloides , Animales , Antiprotozoarios/administración & dosificación , Benzodioxoles , Cricetinae , Portadores de Fármacos , Leishmaniasis Visceral/tratamiento farmacológico , Liposomas , Pruebas de Función Hepática , Macrófagos/parasitología , Manosa/administración & dosificación , Mesocricetus , Piperidinas/administración & dosificación , Alcamidas Poliinsaturadas , Bazo/parasitología
3.
Indian J Biochem Biophys ; 1995 Jun; 32(3): 147-51
Artículo en Inglés | IMSEAR | ID: sea-28833

RESUMEN

Asiaticoside, a plant glycoside with rhamnose as end sugar and having microbicidal properties was tested against Mycobacterium leprae and Mycobacterium tuberculosis both in vivo and in vitro. As rhamnose is reported to have no tissue specificity, corchorusin D having glucose as end sugar was used for targeting with an equimolar proportion of asiaticoside in liposomal form for testing the drug value. Results showed that liposomal asiaticoside had better microbicidal property against M. leprae and M. tuberculosis when compared to that of free asiaticoside whereas liposomes containing asiaticoside and corchorusin D were found to be equally or more active in comparison to liposomal asiaticoside alone. It is inferred that appropriate glycosides, if used in liposomal form (incorporated or covalently grafted) have enhanced drug efficacy and such glycoside bearing liposomes as targeted delivery systems could be used for chemotherapeutic control of several other diseases.


Asunto(s)
Animales , Portadores de Fármacos , Femenino , Lepra/tratamiento farmacológico , Liposomas , Macrófagos/efectos de los fármacos , Masculino , Ratones , Mycobacterium leprae , Mycobacterium tuberculosis , Triterpenos/administración & dosificación , Tuberculosis/tratamiento farmacológico
4.
Indian J Biochem Biophys ; 1993 Oct; 30(5): 277-81
Artículo en Inglés | IMSEAR | ID: sea-28191

RESUMEN

Normal hepatic microsomal membranes when exposed in vitro to different free radicals, cause membrane damage by lipid peroxidation which could be monitored by the analysis of malonaldehyde formation and measurement of membrane microviscosity. Lipid peroxidation in vivo, when examined in hepatic microsomal membranes in experimental Leishmaniasis, reveals a direct relationship between membrane microviscosity and the extent of lipid peroxidation. Scavengers of free radicals and peroxides such as superoxide dismutase (SOD) for O2.-, mannitol for (OH.) and catalase for H2O2 in modest amounts were used for preventing the membrane damage caused by lipid peroxidation.


Asunto(s)
Animales , Depuradores de Radicales Libres , Membranas Intracelulares/efectos de los fármacos , Leishmania donovani , Leishmaniasis Visceral/metabolismo , Peroxidación de Lípido/efectos de los fármacos , Malondialdehído/metabolismo , Ratones , Ratones Endogámicos BALB C , Microsomas Hepáticos/efectos de los fármacos , Oxidantes/farmacología , Valores de Referencia
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