Brain histomorphology in protein deprived rhesus monkeys with fatal malarial infection.

Healthy and protein deprived rhesus monkeys were inoculated with a virulent strain of Plasmodium knowlesi, to determine the morphological changes in the brain and to establish whether this model could be utilised as an experimental model for cerebral malaria. The histomorphological changes produced in the brain did not correspond with the changes conforming to those of cerebral malaria. The changes observed in healthy controls were cerebral oedema, high percentage of parasitised RBCs in the cerebral capillaries, with prominent and, at places, disrupted endothelium. In the protein deprived animals, cerebral oedema was the only conspicuous feature. It appears that the P. knowlesi-rhesus monkey combination is not suitable as an experimental model for cerebral malaria.

Malignant tumours of the digestive tract. A twenty five year study.

A twenty five year retrospective study of malignant tumours was carried out. Malignant digestive tract tumours were about 10% of the total. Segment distribution of the lesion showed highest incidence in large intestine (43.3 percent), oroparynx (34.5 percent), stomach (11.3 percent), oesophagus (6.5 percent) and small intestine (4.4 percent). The maximum cases (74.2 percent) were between 31-60 years, the youngest being a two month old female with rhabdomyosarcoma orpharynx and the oldest a 82 year old male with squamous cell carcinoma anal canal.