RESUMEN
Osteoporosis is a chronic disease characterized by a decrease in bone mineral density [BMD] and corruption of the microarchitectural structure of bone tissue. It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase [ALP] measurements were performed. Obtained results were compared with that of alendronate. Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn't prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn't prevent osteoporosis in ovariectomised rats
Asunto(s)
Femenino , Animales de Laboratorio , Metiltirosinas , Ratas , Osteoclastos/efectos de los fármacos , Prednisolona , Prednisolona/efectos adversos , Combinación de Medicamentos , Ovariectomía/efectos adversos , Osteoblastos/efectos de los fármacos , Densidad Ósea/efectos de los fármacos , Metilprednisolona/efectos adversos , Metilprednisolona , Osteocalcina/efectos de los fármacos , Fosfatasa Alcalina , Alendronato , Resultado del TratamientoRESUMEN
Melatonin is a powerful endogenous antioxidant and it may play a role in prevention of radiation-induced damage. The aim of this study was to investigate the effect of melatonin on bone mineral density in rats receiving radiation. Sprague Dawley rats were divided into four groups. Group 1 [control group] received neither melatonin nor radiation [control group]. Group 2 [Mel group] was administered intraperitoneal injections of 5mg/kg melatonin daily for ten days. Group 3 [RT group] and Group 4 were exposed to total cranium radiation of 5 Gy in a single dose by using a cobalt-60 teletherapy unit. In addition to irradiation, group 4 [RT + Mel group] was administered 5mg/kg of melatonin intraperitoneally. At the end of the 10th day, the rats' cranium and vertebrae bone mineral densities [BMDs] were measured. When cranial BMDs were evaluated, statistically more significant BMD increases were seen in the Mel group and the RT + Mel groups than in the control group. No significant difference was seen in the Mel group versus the RT + Mel group; however, there was a significant difference between RT and RT + Mel groups. When vertebral BMDs were evaluated, the only significant difference was found between the control and Mel groups. We think that melatonin is a radioprotective agent. However, we would like to emphasize that further studies are needed before clinical trials with melatonin are initiated