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Renal dysfunction is common in chronic liver diseases. The cause of renal dysfunction is either multi-organ involvement in acute conditions or secondary to advanced liver diseases. The present study was undertaken to assess the renal function test in chronic liver diseases and find out the association of alteration of renal function with gradation of liver diseases (assessed by child –pugh criteria) and find out the association of alteration of renal functions among the case of chronic liver disease of different aetiology. Methods: This prospective cross sectional study was conducted in the Department of Medicine, Shri. B. M. Patil Medical College, Hospital & Research Centre, Vijayapur during November 2016 to August 2018 with 65 case of chronic liver diseases after considering the exclusion criteria. The patient were interviewed with predesigned and pre tested schedule examined clinically followed by some laboratory investigation relevant to diagnose the aetiology of chronic liver diseases, and to assess the severity of renal dysfunction. Statistical analysis was done by appropriate statistical software including but not restricted to MS Excel, SPSS ver.20 Results: Majority of the patients were male(90.8%) and the mean age of the patients was 45.78 ±13.19 years. 72.2% patients suffered from Alcoholic liver diseases while 13.9% and 10.8% patients had chronic hepatitis B and chronic hepatitis C respectively. Two patients had Nonalcoholic steatohepatitis. It was observed that 36.9% patients had renal dysfunction and most. Conclusion: This study emphasizes the fact that we should be more vigilant when treating Chronic Liver Disease (CLD) patients, regarding their renal function, as proper screening, prevention and treatment of renal dysfunction can decrease morbidity and mortality.
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Background: 1.Effect of atropinization with different methods.2.Outcomes in terms of duration of hospital stay and patients recovery. Methodology: An open-label randomized clinical trial was conducted in, Shri B M Patil Medical College Hospital and Reasearchcentre, Vijyapura, Karnataka in 108 individuals with OPC poisoning .We compared two groups that used a titrated dosing protocol based on a structured monitoring sheet for atropineinfusion with another group using an ‘ad hoc’ regime. The aim was to compare the efficacy andsafety of conventional bolus doses with individualized incremental doses of atropine for atropinization followed by continuous atropine infusion for management of OPC poisoning. Results: Out of 108 patients ,54 patients received conventional bolus dose atropine (group A) and 54 patient received rapidly incremental doses of atropine followed by infusion (group B).36 subjects analysed in group A and 32 in group B for moderate to severe poisoning.The mortality in group A was 11.1%(4/36) and in group B was 6.3%(2/32).The mean duration of atropinization in group A was 5.8hrs (348)in minutes compared to time 26.9minutes for group B. Conclusion: Administration of atropine using a fixed algorithm is easy and effective in providing the atropine requirement in management of early phase of acute OPC poisoning.Rapid incremental dose atropinization followed by atropine infusion reduces mortality and morbidity from OPC poisoning and shortens the length of hospital stay and early recovery .Incremental atropine and infusion should become the treatment of choice for OPC poisoning.
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Introduction: In type 2 diabetes mellitus, lipid abnormalities are almost the rule and is associated with a cluster of interrelated plasma lipid and lipoprotein abnormalities that are all recognized as major risk factors for coronary artery disease and other macro vascular complications. Present study aimed to assess the lipid profile in type 2 diabetic individuals in comparison with non-diabetic individuals. Materials and methods: An observational study was conducted at outpatient and Inpatient department in BLDEU’S Shri. B.M. Patil Medical College Hospital and Research Centre. The sample size was 250 of which 125 were type 2 diabetes mellitus patients who were studied as cases and 125 non diabetics were taken as controls and there lipid profile were estimated and the results obtained were statistically computed. Results: In the present study the results obtained were in cases (type 2 diabetes mellitus) values were as follows – LDL 117.99 ± 49.28, TC 196.77 ± 73.6, TG 186.05 ± 128.32, HDL 38.72 ± 12.5, VLDL 34.06 ± 19.65. These values were much higher as compared to controls (p<0.05). Conclusion: It was observed that in type 2 diabetes mellitus patient’s lipid profile is significantly altered as compared to non-diabetic patients and hence regular monitoring of lipid profiles in such patients is warranted.