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Chinese Journal of Hepatology ; (12): 616-619, 2014.
Artículo en Chino | WPRIM | ID: wpr-313992

RESUMEN

<p><b>OBJECTIVE</b>To gain insights into the role of forkhead box protein 3 (Foxp3) in the pathogenesis of hepatocellular carcinoma (HCC) by performing a comparative analysis of Foxp3 mRNA expression and promoter methylation status in HCC and normal liver tissues.</p><p><b>METHODS</b>Thirty-nine HCC and 13 normal liver tissue specimens were evaluated by real-time quantitative PCR and pyrosequencing to measure the expression of Foxp3 mRNA and determine the methylation status of its promoter, respectively. Statistical analyses of the data were conducted by rank-sum test and Spearman's rank correlation coefficient test.</p><p><b>RESULTS</b>The HCC specimens showed significantly higher mRNA expression of Foxp3 (vs. normal liver tissues, Z =-2.770, P =0.0056). Moreover, the HCC specimens showed significant hypomethylation of the Foxp3 promoter site A (vs. normal liver tissues, Z =2.118, P =0.0339), and the Foxp3 mRNA level was negatively correlated with the methylation of site A (rs =-0.344, P =0.046). None of the other four sites in the Foxp3 promoter showed a significant difference in methylation, and the overall methylation was not significantly different between the HCC and normal liver tissues.</p><p><b>CONCLUSION</b>Overexpression and low methylation of Foxp3 may be involved in the oncogenic and progression processes of HCC.</p>


Asunto(s)
Femenino , Humanos , Masculino , Persona de Mediana Edad , Carcinoma Hepatocelular , Metabolismo , Patología , Islas de CpG , Metilación de ADN , Factores de Transcripción Forkhead , Genética , Metabolismo , Hígado , Metabolismo , Patología , Neoplasias Hepáticas , Metabolismo , Patología , Regiones Promotoras Genéticas , ARN Mensajero , Genética
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