RESUMEN
Objective:To investigate the clinical efficacy of Euthyrox and selenium yeast tablets combined with seaweed Yuhu decoction in the treatment of Hashimoto's thyroiditis complicated with hypothyroidism.Methods:The prospective design was used to study 147 patients with Hashimoto's thyroiditis and hypothyroidism in Shengli Oilfield Central Hospital from January 2015 to July 2017. According to different treatment plans, the subjects were randomly divided into 3 groups. Group A ( n=46) was given Euthyrox, group B ( n=43) was given Euthyrox+selenium yeast tablets, and group C ( n=58) was given Euthyrox+selenium yeast tablets+seaweed Yuhu decoction. After 3 months of treatment, the clinical efficacy, thyroid function [free thyroxine (FT 4), thyroid stimulating hormone (TSH), free triiodothyronine (FT 3)], thyroid autoantibody [thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb)] and T lymphocyte subsets (CD3 +, CD4 +, CD8 +, CD4 +/CD8 +) levels were compared among the 3 groups. Results:The total effective rates [67.39% (31/46), 76.74% (33/43), 93.10% (54/58)] of the 3 groups were compared, the difference was statistically significant (χ 2=11.237, P < 0.05); the total effective rate of group C was significantly higher than that of group A and group B (χ 2=10.282, 12.382, P < 0.05). After treatment, the levels of FT 4 and FT 3 in group C [(18.16 ± 2.79), (5.06 ± 0.80) pg/ml] were significantly higher than those in group A and group B [(13.52 ± 2.98), (3.56 ± 0.58), (15.62 ± 3.04), (4.22 ± 0.49) pg/ml, P < 0.05], TSH level [(4.02 ± 2.14) mU/L] was significantly lower than that in group A and group B [(13.42 ± 3.41), (6.63 ± 3.19) mU/L, P < 0.05]. After treatment, the levels of TGAb and TPOAb in group C were significantly lower than those in group A and group B ( P < 0.05). After treatment, the levels of CD3 +, CD4 +, CD4 +/CD8 + in group C were significantly higher than those in group A and group B ( P < 0.05). Conclusion:Euthyrox and selenium yeast tablets combined with seaweed Yuhu decoction has a significant effect in the treatment of Hashimoto's thyroiditis complicated with hypothyroidism, and reduces the level of thyroid autoantibody, and improves the immune function of the body, which is worthy of promotion and application.