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Objective To evaluate the effect of obesity on the potency of propofol for sedation.Methods Sixty patients of both sexes, aged 35-55 yr, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ , scheduled for elective operation under general anesthesia, were enrolled in the study.The patients were divided into 2 groups (n=30 each) according to the body mass index (BMI) : normal body weight (BMI ＜ 25 kg/m2) group (group C) and obesity (BMI 30-40 kg/m2) group (group O).No patients received premedication.Propofol was given by target-controlled infusion.The initial target plasma concentration of propofol was set at 1.2 μg/ml.After the target concentration was steadily maintained for 30 s, it was increased in 0.3 μg/ml increment until the patients lost consciousness (OAA/S score =1).The target plasma concentration of propofol was recorded during each period.The median effective concentration (EC50) and 95％ confidence interval of propofol for loss of consciousness was calculated using probit analysis.Results The EC50 and 95％ confidence interval of propofol for loss of consciousness were 3.82 (3.73-3.90) and 3.29 (3.20-3.37) μg/ml in group C and group O, respectively.Compared with group C, the EC50 was significantly decreased in group O (P＜0.05).Conclusion Obesity can enhance the potency of propofol for sedation.
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OBJECTIVE@#The aim of current work was to investigate the methodology and effect of dual U-shaped mucosal flap repair plus local dilatation for the treatment of nasopharyngeal atresia.@*METHOD@#Nine patients with nasopharyngeal stenosis were treated with dual U-shaped flap to repair the wound of retropharyngeal and soft palate mucosa. and then dilated by implanting a silicone tube.@*RESULT@#The silicone tube was removed 6 months after the operation. The transverse diameter of nasopharynx maintained at about 2.0 - 2.5 cm, and anteroposterior diameter at about 1.0 cm. All cases had good nasal patency except velopharyngeal insufficiency and nasal regurgitation of food. After a 2 years follow-up, all cases had a good result except one still had the nasal regurgitation of food.@*CONCLUSION@#U-shaped mucosal flap repair with local dilatation is an effective method for treatment of nasopharyngeal atresia.