RESUMEN
Organophosphorus compound poisoning is used most commonly for suicidal attempts which is seen frequently in farmers of younger age group of lower socio-economic status from rural areas. The aim of study is to know the clinical profile of organophosphate compound poisoning and to identify the factors which help in predicting the need for ventilatory support in this poisoning. Methods: A hospital based prospective cross sectional study was conducted with 100 patients to analyze the clinical profile of organophosphate compound poisoning and identify the factors which help in predicting the need for ventilatory support in organophosphorous compound poisoning. Results: Majority of the patients were in the age group of 21-30 years. The mean age of the patients was 31.96 ± 14.12 years. The route of exposure was oral in all the patients. The most common organophosphorus compound consumed in our study was Malathion (28%) ,46 (46%) patients had very poor GCS score (≤7), 38 (38%) patients had low serum cholinesterase levels (≤2100 IU/L),9 (9%) patients had amylase levels>140 U/L, 43 (43%) patients required ventilatory support while 57 (57%) patients did not require ventilator support. Among patients with fasciculations 64% were on ventilatory support. There was significant association of fasciculations and ventilatory support. 87 (87%) patients survived while 13 (13%) patients died in our study. All patients that died were on ventilatory support. Conclusion: Clinical and biochemical parameters such as greater the time lag from consumption of OP poison till getting specific treatment, Lower GCS scoring, Generalized Fasciculation’s, Low cholinesterase levels were strong predictors for the need for Assisted Ventilation in OP poisoning.
RESUMEN
The present study was undertaken to evaluate the adaptogenic activity of ethanol (EtHI), ethyl acetate (EAHI) fractions of Habenaria intermedia D. Don, Orchidaceae (HI), tubers using immobilization induced acute stress (AS), chronic stress (CS) and swimming induced stress in experimental animals. The tested doses of EtHI (100 and 200 mg/kg, p.o.) and higher dose of EAHI (200 mg/kg, p.o.) normalized altered serum biochemical parameters and the severity of ulcers in both AS and CS. EAHI and EtHI restored the hyperthrophy of adrenal gland and atrophy of spleen and thymus gland in AS and CS. Greater swimming time was noted in the mice pretreated with EtHI and EAHI. Levels of adrenal ascorbic acid and cortisol were restored significantly. EAHI exhibited prominent scavenging effect of DPPH, hydroxyl radical and lipid peroxidation in vitro. Phytochemical studies resulted in the isolation of scopoletin and gallic acid as marker compounds. Our results proved the traditional claim of HI as anti-stress/adaptogen in Ayurvdea.