RESUMEN
Objective:To evaluate the association between serum P,E2 and progesterone/estradiol ratio (P/E2) on pregnancy outcome in IVF/ICSI cycles with long agonist protocol.Methods:A review of complete data of 539 women underwent fresh IVF/ICSI cycles with long agonist protocol from January 2014 to February 2017 was done.Data were stratified into three groups according to the number of oocytes retrieved:low(≤4 oocytes obtained),intermediate (5-19 oocytes obtained),and high ovarian response (≥20 oocytes obtained) group.Receiver operating characteristics curve(ROC curve) analysis was performed to determine the cut-off value for P and P/E2 detrimental for pregnancy.Results:.With the increase of serum P level on daily hCG,the pregnancy rate was gradually decreased.The overall P level was 3.408 nmol/L,with the equivalent sensitivity and specifity were 55％,The P level of moderate and high responders was 3.408 nmol/L,with the equivalent sensitivity and specifity were 56％.Equivalent sensitivity and specificity of 62％ for P level of 4.042 nmol/L.The pregnancy rate (31.4％) in patients with P/E2 ≤0.49 was significantly higher than that in patients(23.4％) with P/E2 ＞0.49 (P=0.041),but there was no significant difference in fertilization rate and cleavage rate between them(P ＞ 0.05).Pregnancy rate,fertilization rate and cleavage rate at different E2 levels on daily hCG also had no statistical significance(P＞0.05).Conclusions:Level of serum P and P/E2 ratio on the day of human chorionic gonadotropin both are significant predictors for pregnancy outcome in IVF/ICSI cycles with long agonist protocol.