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1.
Braz. j. med. biol. res ; 37(5): 691-695, May 2004. ilus
Artículo en Inglés | LILACS | ID: lil-357556

RESUMEN

Hepatitis C virus (HCV) was first described in 1989 as the putative viral agent of non-A non-B hepatitis. It is a member of the Flaviviridae family and has been recognized as the major causative agent of chronic liver disease, including chronic active hepatitis, cirrhosis and hepatocellular carcinoma. HCV is a positive RNA virus with a genome containing approximately 9500 nucleotides. It has an open reading frame that encodes a large polyprotein of about 3000 amino acids and is characterized by extensive genetic diversity. HCV has been classified into at least 6 major genotypes with many subtypes and circulates within an infected individual as a number of closely related but distinct variants known as quasispecies. This article reviews aspects of the molecular biology of HCV and their clinical implication.


Asunto(s)
Humanos , Regiones no Traducidas 3' , Genoma Viral , Genotipo , Variación Genética , Biología Molecular , Proteínas no Estructurales Virales , Proteínas Estructurales Virales
2.
Indian J Pediatr ; 1997 Nov-Dec; 64(6): 887-91
Artículo en Inglés | IMSEAR | ID: sea-79567

RESUMEN

We prospectively applied a protocol used to sedate children who required a liver biopsy. Sixty liver biopsies were performed on thirty pediatric patients to assess the effects of treatment. Sixteen patients had Type 1 Gaucher's disease of which seven had a platelet count between 50-100,000/mm3. All seven had bleeding time performed and when indicated, intravenous DDAVP (1-deamino-8-D-arginine vasopressin) was used to improve hemostasis. Fourteen patients had Niemann-Pick disease type C of which eight were significantly demented and uncooperative. Before liver biopsy, all patients were sedated with the following regimen: oral chlorpromazine (1 mg/kg) followed one hour later by intravenous meperidine (1 mg/kg) and pentobarbital (maximum dosage 6 mg/kg) administered by slow intravenous injection. Liver biopsies were obtained safely on all patients. Only 1 patient (2%) developed a potentially serious complication: an obstructed airway which was readily corrected by simple repositioning. Transient less serious complications occurred in another 7 patients (12%). There was no long term sequalae of the biopsy procedures. Our study indicates that with appropriate patient selection, this sedation protocol may be useful in pediatric patients requiring a liver biopsy.


Asunto(s)
Adolescente , Biopsia con Aguja , Niño , Preescolar , Sedación Consciente/métodos , Femenino , Humanos , Hígado/patología , Enfermedades por Almacenamiento Lisosomal/diagnóstico , Masculino , Estudios Prospectivos , Sensibilidad y Especificidad , Resultado del Tratamiento
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