RESUMEN
Objective To explore sedation effects of fentanyl and midazolam during mechanical ventilation.Methods 40 neonates admitted for purposes of mechanical ventilation were divided into two groups randomly ,20 cases of fentanyl, midazolam group of 20 patients. Group of fentany 2 ～5 μg · kg-1 · h-1 , continuously intravenous injection. Load of midazolam was 0. 1mg/kg by injection,continue to maintain by 0.05mg · kg-1 · h-1. Sedative effects were observed duration of mechanical ventilation and heart rate monitoring during the treatment the in two groups(HR),respiration(R) ,non-invasive mean arterial blood pressure(MBP). Results HR、R and MBP of Fentanyl group had no significant difference between after treatment 30min ,6h, 12h and 24h and before treatment (all P ＞ 0.05). HR、 R and MBP of midazolam group had significant difference between after treatment 30min, 6h, 12h and 24h and before treatment(all P ＜ 0. 05). Fentanyl group took shorter time and lower pressure duration of mechanical ventilation(all P ＜ 0.05). Two of the ideal number of cases sedation was no significant difference(P ＞ 0.05). Conclusion The sedation effect of fentanyl in the neonatal mechanical ventilation was better than midazolam, and impact on circulation and respiration was small, and the time from the ventilator was shorter.