RESUMEN
We resuscitated unanesthetized bled sheep (bled volume = 1.2-1.7 liters) with 200 ml of hypetonic saline/dextran 70 infused either through a peripheral vein (n=6) or directly into the red marrow of the sternum (n = 6). Intraosseous infusion of the viscous 7.5% NaCl/6% dextran solution required 2-4 min. Plasma sodium was rapidly increased to the same level n both groups demonstrating equally rapid entry into the vascular space. Both regimens provide rapid and sustained normalization of arterial pressure and cardiac output. No significant differences between the two groups were apparent for any measured variable. Intraosseous infusion of hypertonic resuscitation fluids merits further research to evaluate the safety and efficacy for prehspital treatment of hypovolemia and trauma