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Rev. Inst. Med. Trop. Säo Paulo ; 34(4): 303-7, jul.-ago. 1992. tab
Artículo en Inglés | LILACS | ID: lil-134521

RESUMEN

C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells were transferred from infected CY-treated to infected untreated rats, achieving significant specific inhibition in footpad swelling to coccidioidin in recipients, attributable to a suppressor T cell subpopulation induced by greater fungal antigen concentration arising from widespread C. immitis dissemination in immunosuppressed animals. NK activity proved similar regardless of CY treatment. Lastly, chronically infected rats presented increased colony forming units count after several weekly doses of CY, as happens in immunosuppressed patients harbouring a previous infection


Asunto(s)
Animales , Masculino , Coccidioidomicosis/inmunología , Huésped Inmunocomprometido/inmunología , Enfermedad Crónica , Ensayo de Unidades Formadoras de Colonias , Hipersensibilidad Tardía/inmunología , Terapia de Inmunosupresión/métodos , Células Asesinas Naturales/inmunología , Ratas , Ratas Endogámicas BUF , Bazo/citología , Bazo/inmunología , Bazo/trasplante
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