Hepatocellular Carcinoma with Severe Hypoglycemia: Involvement of Insulin-ike Growth Factor I, II and Insulin-ike Growth Factor Binding Proteins / 대한간학회지

We report a case of hepatocellular carcinoma presented with severe hypoglycemia. Computerized tomography and ultrasonography revealed a massive bilateral tumor with portal vein thrombosis. The levels of IGF-I (113 ng/mL) and IGFBP- (815 ng/mL) measured in the plasma, were lower than normal range. There was strong immunoreactivity of IGF- and IGF-I in immunohistochemical stain of tumor cells.