1.
Braz. j. med. biol. res
;
22(9): 1151-4, 1989. ilus
Artículo
en Inglés
| LILACS
| ID: lil-83193
RESUMEN
The chemotactic activity of PAF-acether was compared with that of tetrapeptide eosinophil chemotactic factors of anaphylaxis (ECF-A, Ala-Gly-Ser Glu and Val-Gly-Ser-Glu) using eosinophils obtained from the peritoneal cavity of normal rats. Cells were isolated by separation over discontinuous metrizamide gradients which resulted in eosinophil suspensions of 80 to 90% purity. PAF-acether produced 7-fold greater than the maximal activity obtained with the ECF-A-tetrapeptides. BN 52021 and WEB 2086 inhibited PAF-acether-induced eosinophil chemotaxis in a dose-dependent manner, suggesting that this phenomenon is mediated by specific PAF-acether receptors
Asunto(s)
Ratas , Animales , Masculino , Eosinófilos/fisiología , Factor de Activación Plaquetaria/antagonistas & inhibidores , Factores Quimiotácticos Eosinófilos/farmacología , Técnicas In Vitro , Cavidad Peritoneal/citología , Azepinas/farmacología , Movimiento Celular , Quimiotaxis , Lactonas/farmacología , Ratas Endogámicas , Triazinas/farmacología
2.
Braz. j. med. biol. res
;
21(2): 337-40, 1988. tab
Artículo
en Inglés
| LILACS
| ID: lil-57258
3.
Braz. j. med. biol. res
;
20(5): 487-94, 1987. ilus
Artículo
en Inglés
| LILACS
| ID: lil-47499