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1.
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 1030-1035, 2013.
Artículo en Chino | WPRIM | ID: wpr-359262

RESUMEN

In clinical research on complementary and integrative medicine, experts and scientists have often pursued a research agenda in spite of an incomplete understanding of the needs of end users. Consequently, the majority of previous clinical trials have mainly assessed the efficacy of interventions. Scant data is available on their effectiveness. Comparative effectiveness research (CER) promises to support decision makers by generating evidence that compares the benefits and harms of best care options. This evidence, more generalizable than evidence generated by traditional randomized clinical trials (RCTs), is better suited to inform real-world care decisions. An emphasis on CER supports the development of the evidence base for clinical and policy decision-making. Whereas in most areas of complementary and integrative medicine data on CER is scarce, available acupuncture research already contributes to CER evidence. This paper will introduce CER and make suggestions for future research.


Asunto(s)
Investigación sobre la Eficacia Comparativa , Medicina Integrativa , Ensayos Clínicos Controlados Aleatorios como Asunto , Proyectos de Investigación
2.
Journal of Neurogastroenterology and Motility ; : 305-316, 2012.
Artículo en Inglés | WPRIM | ID: wpr-22757

RESUMEN

BACKGROUND/AIMS: Patients with irritable bowel syndrome (IBS) are characterized by abnormal central processing with altered brain activation in response to visceral nociceptive signals. The effect of electroacupuncture (EA) on IBS patients is unclear. The study is set to study the effect of EA on brain activation during noxious rectal distension in IBS patients using a randomized sham-controlled model. METHODS: Thirty IBS-diarrhea patients were randomized to true electroacupuncture or sham acupuncture. Functional MRI was performed to evaluate cerebral activation at the following time points: (1) baseline when there was rectal distension only, (2) rectal distension during application of EA, (3) rectal distension after cessation of EA and (4) EA alone with no rectal distension. Group comparison was made under each condition using SPM5 program. RESULTS: Rectal distension induced significant activation of the anterior cingulated cortex, prefrontal cortex, thalamus, temporal regions and cerebellum at baseline. During and immediately after EA, increased cerebral activation from baseline was observed in the anterior cingulated cortex, bilateral prefrontal cortex, thalamus, temporal regions and right insula in both groups. However, true electroacupuncture led to significantly higher activation at right insula, as well as pulvinar and medial nucleus of the thalamus when compared to sham acupuncture. CONCLUSIONS: We postulate that acupuncture might have the potential effect of pain modulation in IBS by 2 actions: (1) modulation of serotonin pathway at insula and (2) modulation of mood and affection in higher cortical center via ascending pathway at the pulvinar and medial nucleus of the thalamus.


Asunto(s)
Humanos , Acupuntura , Terapia por Acupuntura , Encéfalo , Cerebelo , Electroacupuntura , Síndrome del Colon Irritable , Imagen por Resonancia Magnética , Espectroscopía de Resonancia Magnética , Magnetismo , Imanes , Vías Nerviosas , Percepción del Dolor , Corteza Prefrontal , Pulvinar , Salicilamidas , Serotonina , Tálamo
3.
Journal of Neurogastroenterology and Motility ; : 306-314, 2010.
Artículo en Inglés | WPRIM | ID: wpr-79062

RESUMEN

BACKGROUND/AIMS: While it is well established that acupuncture relieves somatic pain, its therapeutic effect on visceral pain such as irritable bowel syndrome (IBS) is unclear. We evaluated the effect of acupuncture in treating visceral hyperalgesia in an animal model. METHODS: Sprague-Dawley rats (n = 8 per group) with prior neonatal maternal separation stress were randomly allocated to receive 3-day treatment of either electroacupuncture (EA) or sham acupuncture at acupoint ST-36. Another group of rats without prior maternal separation was included as non-handled controls. Colorectal distension was performed on the day after acupuncture treatment. The 3 groups were compared for pain threshold as determined by abdominal withdrawal reflex and visceromotor response as measured by electromyogram. Colon, spinal cord, and brainstem were sampled for topographic distribution and quantitative assessment of serotonin and Fos expression by immunohistochemistry. RESULTS: Rats in EA group had significantly higher pain threshold compared to those in sham acpuncture group (25.0 +/- 5.7 mmHg vs 18.7 +/- 5.2 mmHg, p = 0.01) and it was comparable with that of non-handled treatment naive controls (29.4 +/- 9.3 mmHg, p = 0.28). They also had lower visceromotor response as measured by electromyogram compared to those received sham acupuncture at all colorectal distension pressures. EA significantly suppressed Fos expression in doral raphe nuclei of brainstem, superficial dorsal horn of spinal cord and colonic epithelium but suppressed 5-HT expression only in brainstem and spinal cord. CONCLUSIONS: Electro acupuncture attenuates visceral hyperlagesia through down-regulation of central serotonergic activities in the brain-gut axis.


Asunto(s)
Animales , Ratas , Acupuntura , Puntos de Acupuntura , Vértebra Cervical Axis , Benzodiazepinas , Tronco Encefálico , Colon , Regulación hacia Abajo , Electroacupuntura , Epitelio , Cuernos , Hiperalgesia , Inmunohistoquímica , Síndrome del Colon Irritable , Modelos Animales , Dolor Nociceptivo , Umbral del Dolor , Núcleos del Rafe , Ratas Sprague-Dawley , Reflejo , Salicilamidas , Serotonina , Médula Espinal , Dolor Visceral
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