RESUMEN
Objective@#This study aimed to evaluate the unexplored relationship between BDNF methylation, long-term outcomes, and its interaction with suicidal ideation (SI), which is closely associated with both BDNF expression and stroke outcomes. @*Methods@#A total of 278 stroke patients were assessed for BDNF methylation status and SI using suicide-related item in the Montgomery–Åsberg Depression Rating Scale at 2 weeks post-stroke. We investigated the incidence of composite cerebro-cardiovascular events (CCVEs) during an 8−14-year period after the initial stroke as long-term stroke outcome.We conducted Cox regression models adjusted for covariates to evaluate the association between BDNF methylation status and CCVEs, as well as its interaction with post-stroke SI at 2 weeks. @*Results@#Higher methylation status of CpG 1, 3, and 5, but not the average value, predicted a greater number of composite CCVEs during 8−14 years following the stroke. The associations between a higher methylation status of CpGs 1, 3, 5, and 8, as well as the average BDNF methylation value, and a greater number of composite CCVEs, were prominent in patients who had post-stroke SI at 2 weeks. Notably, a significant interaction between methylation status and SI on composite CCVEs was observed only for CpG 8. @*Conclusion@#The significant association between BDNF methylation and poor long-term stroke outcomes, particularly amplified in individuals who had post-stroke SI at 2 weeks, suggested that evaluating the biological marker status of BDNF methylation along with assessing SI during the acute phase of stroke can help predict long-term outcomes.
RESUMEN
Objective@#We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS). @*Methods@#Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the“suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates. @*Results@#Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group. @*Conclusion@#By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.
RESUMEN
BACKGROUND: Nasotracheal intubation is one of techniques of airway management that is essential for the emergency physician to master. It is very important to determine the optimal initial depth of tube in nasotracheal intubation, prior to obtaining a chest radiograph. The average distance from the external naris to the carina is 32cm in the adult male and 27 to 28cm in the adult female in American. We thought that this distance would be inappropriate to Korean adults because of the difference of body habitus. So we studied the proper depth of nasotracheal tube in korean adults and evaluated the factors influencing to that distance. METHODS: A prospective study was performed to determine the distance from the external naris to the carina in 127 Korean adults examined by flexible fiberoptic bronchoscopy from October 1998 to August 1999. In addition, the influence of age, height and weight to that distance was evaluated in korean adults. RESULT:S: The distance from the external naris to the carina in Korean adults was 31.0 +/-1.3 cm in male and 27.6 +/-1.6 cm in female. That distance was positive related to height and weight, but not to age. CONCLUSION: If the tip of the nasotracheal tube be placed at 2cm above the carina, proper depth of nasotracheal tube should be 29cm in male and 26cm in female in Korean adults. And the distance from the external naris to the carina was related to height and weight.