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Journal of the Korean Neurological Association ; : 44-49, 2000.
Artículo en Coreano | WPRIM | ID: wpr-104077

RESUMEN

BACKGROUND: In order to understand the pathogenesis and symptom development in Alzheimer's disease (AD), we attempted to develop a computer model for memory impairment in this study. METHODS: We made a simple autoassocia-tive memory network, first developed by Hopfield, which remembers numbers or patterns, transformed it into an AD model by pruning synapses, and measured its memory performance as a function of synaptic deletion. RESULTS: Decline in memory performance was measured as amount of synaptic loss increased and its mode of decline varied with different synaptic pruning methods. CONCLUSIONS: The developed computer model demonstrated how synaptic loss could cause memory impairment through a series of computer simulations, and suggested a new way of research in AD.


Asunto(s)
Enfermedad de Alzheimer , Simulación por Computador , Memoria , Redes Neurales de la Computación , Sinapsis
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