Effect of the prophylactic use of antibiotics on wound infection after cleft lip surgery / 华西口腔医学杂志

OBJECTIVES@#To study the effect of preoperative prophylactic use of antibiotics on wound infection in patients with cleft lip.@*METHODS@#Aretrospective study was conducted on the clinical data of 1 361 patients who underwent one-stage cleft lip repair in the Department of Cleft Lip and Palate in West China Hospital of Stomatology, Sichuan University, from January 2015 to November 2018. The patients were divided into two groups according to whether prophylactic antibiotics were used or not. There were 594 patients in the prevention group, including 373 unilateral incomplete cleft lip (UICL) patients, 157 unilateral complete cleft lip (UCCL) patients, 25 bilateral incomplete cleft lip (BICL) patients, 39 bilateral complete cleft lip (BCCL) patients. There were 767 patients in the non-prophylactic group, including 482 UICL patients, 211 UCCL patients, 31 BICL patients, 43 BCCL patients. The relationship between preoperative and postoperative leukocyte count, preoperative and postoperative body temperature, and postoperative wound infection were compared between the two groups.@*RESULTS@#No significant difference was observed in the leukocyte count and body temperature between both groups (@*CONCLUSIONS@#The preoperative prophylactic use of antibiotics has no significant effect on the incidence of postoperative infection in patients undergoing cleft lip repair.

Research progress on the relationship between breast artery calcification and cardiovascular disease / 解放军医学杂志

As a disease with high morbidity and mortality, cardiovascular disease always threatens human health at all times. Exploring the risk factors has always been the research direction of physicians. In recent years, it has been found that breast artery calcification is closely related to the occurrence and development of cardiovascular disease, which is one of the potential risk factors. The present paper reviews the overview, grading methods, incidence and related studies of breast artery calcification and cardiovascular disease, and explores in-depth the correlation between breast artery calcification and cardiovascular disease in order to provide a basis for improving the assessment of cardiovascular disease risk.

Research Progress on Mechanism of Active Components of Traditional Chinese Medicine in Treating Rheumatoid Arthritis Based on Signaling Pathway / 中国实验方剂学杂志

Objective: Rheumatoid arthritis (RA) is one of the most common inflammatory arthropathy diseases, characterized by synovium hyperplasia and progressive destruction of articular cartilage, which is significantly associated with dysfunction and shortening of life span. Drug therapy is the main intervention for RA, but the glucocorticoid and immunosuppressant have many shortcomings in treatment, such as great side effect, slow onset and poor efficacy, while biological agents are too expensive. RA belongs to the category of "arthralgia syndrome" in traditional Chinese medicine (TCM). TCM treatment for RA has a well-established history and multiple advantages such as good curative effect and less side effects, but its mechanism needs to be further studied. Signaling pathway is involved in the pathogenesis and progression of RA, so it is one of the main targets in research on the pathogenesis of RA and related pharmacological research of therapeutic drugs. In recent years, a large number of studies have been carried out on the regulation effect of active components of TCM on RA signaling pathways. These signaling pathways include Wnt signaling pathway, Janus tyrosine kinase (JAK)-signal transducers and transcription activator (STAT) signaling pathway, mitogen-activated protein kinase (MAPKs) signaling pathway, phosphoinositide-3-kinase (PI3K)/serine/protein kinase B (Akt) signaling pathway, nuclear factor-kappa B (NF-κB) signaling pathway, Toll like receptor (TLRs) signaling pathway, receptor activator of the nuclear factor kappa B ligand (RANKL)/receptor activator of the nuclear factor kappa B (RANK)/Osteoprotegerin (OPG) signaling pathway and so on. By reviewing the research results in recent years, we hope to provide ideas and reference for the basic research, development of new drugs and clinical treatment of RA.

The risk factors and preventive measures of hospital infections on preoperative children with cleft lips and palates / 华西口腔医学杂志

OBJECTIVE@#To analyze the risk factors of preoperative upper respiratory infections in children with cleft lips and palate (CLP) and investigate preventive measures to reduce infections and improve the quality of treatments.@*METHODS@#A total of 510 children with CLP of ages 3 years old or younger were selected from hospital cases from June to December 2017. The test group comprised 50 children with upper respiratory infections, whereas the control group comprised 460 children without upper respiratory infections. A t-test and a multivariate logistic analysis were utilized to analyze the risk factors and to investigate the preventive measures.@*RESULTS@#Feeding patterns, the presence of infected companions during hospitalization, and ventilation at night were statistically significant. The feeding patterns and the presence of infected companions during hospitalization were independent risk factors for upper respiratory infections in children with CLP.@*CONCLUSIONS@#Bottle feeding, infected companions during hospitalization, and the absence of window ventilation at night are risk factors for preoperative upper respiratory infections in children 3 years old or younger with CLP. Among the risk factors identified, feeding patterns and the presence of infected companion during hospitalization were the most influential. Medical staff members should streng-then corresponding health education and nursing measures to control the risk factors.

Behavioral pattern in Chinese school-aged children with cleft lip and palate

OBJECTIVE@#To obtain descriptive information of behavioral pattern in Chinese school-aged children with cleft lip and palate.@*METHODS@#A total of 93 cleft lip and palate patients between the age of 6-11 year-old and treated at West China Stomatology Hospital were selected. And another 100 unaffected controls, matched for age and gender, were recruited randomly from a common primary school in Chengdu. Chart review of medical records was used to obtain psychosocial checklists. Scores were compared with published norms and controls to evaluate the risk of problems, separately for three diagnostic groups.@*RESULTS@#The patients group had lower scores of social and academic competencies, especially those with facial deformity or speech problem. No difference was found in the aspect of activity competency. All patients showed elevations in behavior problems. But the type of behavior problems varied in different genders.@*CONCLUSIONS@#Chinese school-aged children with cleft lip and palate are at raised risk for social and academic difficulties. Specific pattern of behavior problems displays differently depending on gender of the patient.

Analysis of psychological conditions of parents of children with cleft lip and palate by using psychological scales before and after psychological treatment / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate the psychological conditions of parents of children with cleft lip and palate, and to discuss the clinical psychological treatment methods of these parents.</p><p><b>METHODS</b>100 parents of children with cleft lip and palate were selected as the parents of children with cleft lip and palate group, and 34 normal adults were selected as the control group. Two groups were tested by the life event scale (LES) and self-rating anxiety scale (SAS) to analyze their psychological states. After the study group was treated by psychological counseling, two groups were tested by the LES and SAS again.</p><p><b>RESULTS</b>The LES total scores of the patients of children with cleft lip and palate had significant differences compared with the normal adults (P < 0.05) before and after psychological counseling, and the LES scores of negative life event of these patients also significantly decreased before and after psychological counseling (P < 0.05). While the SAS total scores of the patients of children with cleft lip and palate had no significant differences compared with the normal adults before and after psychological counseling (P > 0.05).</p><p><b>CONCLUSION</b>Analyzing the psychological conditions of parents of children with cleft lip and palate by using psychological scales and then treating them by counseling, is an effective psychological treatment method.</p>

Psychological nursing after cleft lip and palate surgery with precardium area pain: a case report / 华西口腔医学杂志

A 18-year-old female patient after cleft lip and palate surgery with an uncommon complication-precardium area pain were reported. The psychological treatment and nursing along with routine clinical treatment to the patient were applied. The patient had recovered from the precardium area pain after one week treatment.

Exploring the guide line of clinical treatment on cleft lip and palate / 华西口腔医学杂志

In recent years our research team introduced many foreign patterns to our clinics, kept innovating and exploiting more reasonable modes and methods to cure the cleft patients in the situation of a developing country. Now we concluded the treatment principles, patterns and techniques of the sequential therapy according to the different temporal stages of cleft, from its arising to the evolution, evaluated our therapy results and induced a preliminary guide line of our treating clefts. We sincerely hope this rule could promote the general progress in both clinical treatment and researching.