Relation of muscle indices with metabolic parameters and C-peptide in type 2 diabetes mellitus

Objective: To assess the relation between bioimpedance measurements and metabolic parameters and C-peptide in patient with type 2 diabetes mellitus [DM]. Study Design: Cross-sectional study. Place and Duration of Study: Kartal Dr Lutfi Kirdar Training and Research Hospital, Pendik Kaynarca Diabetes Center, Exercise and Metabolism Unit, between January and March 2015

Methodology: Patients with DM, aged less than 65 years, were assessed for bioimpedance analysis, fasting plasma glucose [FPG], HbA1c, C-peptide levels, triglyceride levels, LDL-cholesterol, and HDL-cholesterol levels. Skeletal muscle index, total muscle index, skeletal muscle percentage, and total muscle percentage were used for muscle-related analyses. Mann-Whitney U-test or independent t-test were used to compare differences between two independent groups. Pearson correlation test or Spearman correlation test were used to find out correlation between variables

Results: A total of 359 DM patients were enrolled in the study. Mean age was 51.6 +/- 8.0 years, and 278 [77.7%] of the participants were females. After adjusting age and gender variables, there was no relation between muscle-related measurements and FPG, triglyceride, LDL-cholesterol [p>0.05]. However, there was muscle-related indexes [MRI] positively correlation with C-peptide and inversely associated with HDL-cholesterol [p<0.05]

Conclusion: Muscle-related indices positively correlated with C-peptide, which showed endogenous insulin reserve

Single gallstone associated with high fasting insulin level

Gallstone [GS] formation is a multifactorial process and one of the associated factors is hyperinsulinemia. The aim of this cross-sectional study was to determine the association between size and count of gallstones, and insulin levels and resistance. The study group composed of 84 patients who have ultrasonographically confirmed gallstone[s]. Insulin level of all participants were measured and insulin resistance was calculated with the homeostasis model assessment of insulin resistance [HOMA-IR] index. All p-values < 0.05 were considered statistically significant. There were 28 patients with single stone and 56 with multiple stones. Mean insulin level was 12.54 +/- 11.66 ml/U [median 9.91 ml/U, IQR 6.33] and 56.3% of patients had insulin resistance. Mean stone size was 7.82 +/- 7.52 mm [median 6 mm and IQR 11.75]. There was a non-significant association and correlation between insulin level and size of GS [p=0.129; r =0.16]. There was significant difference between single stone group and multiple stones group, according to the insulin level

Frequency of ABO/Rhesus blood groups in patients with diabetes mellitus

The correlation between ABO/Rh blood groups and diabetes mellitus is still controversial. The aim of this study was to determine the relationship between ABO/Rhesus blood groups and diabetes in Turkish population. This cross-sectional study was conducted in Istanbul Medeniyet University Goztepe Education and Training Hospital's Diabetes Units. The study group was composed of 421 patients with type-1 diabetes, 484 patients with type-2 diabetes and 432 controls. Blood samples were collected and tested for ABO/Rhesus blood groups. Data was analyzed by SPSS version 17.0. A significant association was found between blood groups and diabetes mellitus. The frequency of AB blood group was significantly higher in type-1 diabetics; and A blood group was significantly higher in type-2 diabetics. Furthermore, Rh negativity were significantly more frequent in type-2 diabetics

Effect of socio-cultural factors on spontaneous abortion in Burdur, Turkey: a population based case-control study

Objective: To determine the sociocultural factors that have effect on spontaneous abortion in Burdur, Turkey

Methods:Study was designed as case-control study. The case group consist of 257 women whose pregnancies ended with spontaneous abortion. The control group consisted of 514 women whose pregnancy continued since 22 weeks and more during the study. Chi-square, and backward LR logistic regression were utilized in analyses

Results:In multifactorial-analyses it was determined that four factors [educational status of women, employment status of women, exposure to physical violence and non-receipt of ANC] created independent risk on spontaneous abortions

Conclusions:Pregnant women with these risk factors should be followed up more frequently and in a more qualified way in primary and secondary and tertiary health institutions

Prevalence of celiac disease in adult type 1 patients with diabetes

Celiac disease, an autoimmune disease, is related to immune mediated intolerance to gluten. Some studies suggest that Celiac Disease was 20 times more frequent in type 1 patients with diabetes. The objective of our study was to evaluate the prevalence of celiac disease in hospital based type 1 diabetic adults. Our study was carried out retrospectively in Medeniyet University Goztepe Training and Educational Hospital in Istanbul between 2012-2013. The cohort comprised 482 type 1 patients with diabetes attending the diabetes outpatient clinic. The data were analyzed by SPSS 10.5 package program. Student's t tests is used for comparative analyses. A p-value less than 0.05 was considered statistically significant. The cohort included 482 type 1 patients with diabetes. Fifty seven of them were not evaluated for Endomysium antibody positivity. Fifteen of the remaining 425 patients were positive for anti endomysial antibody [3.5%]. The prevalence of biopsy proven celiac disease was 2.3% [10/425]. There was no significant difference between Endomysial antibody positive and negative groups in regard of age, sex, or duration of the disease. This study confirms that the celiac disease is common in type 1 diabetic patients. Since a small proportion of celiac patients are symptomatic this disorder should be screened in all adult type 1 patients with diabetes by antiendomysium antibody