RESUMEN
Abstract: Cutaneous mucinoses are a heterogeneous group of dermatoses in which excess deposition of mucin in the dermis gives the skin a waxy appearance, with papules and plaques that can vary from self-healing mucinosis to even disrupting the normal shape of a patient's face, conferring a leonine facies, or be part of life threatening diseases like scleromyxedema. This review will describe the most recent classification on lichen myxedematosus in the generalized (scleromyxedema) and the localized forms, as well as the different organ systems involved in scleromyxedema, diagnostic workup, current management, and prognosis.
Asunto(s)
Humanos , Enfermedades de la Piel/diagnóstico , Enfermedades de la Piel/patología , Escleromixedema/diagnóstico , Escleromixedema/patología , Piel/patología , Enfermedades de la Piel/clasificación , Enfermedades de la Piel/terapia , Escleromixedema/clasificación , Escleromixedema/terapia , Fibroblastos/patología , MucinasRESUMEN
Abstract Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophysiology, clinical features, prevention and treatment of cutaneous graft-versus-host disease. We discuss various insights into the disease's mechanisms and the different treatments for acute and chronic skin graft-versus-host disease.