RESUMEN
Anaphylactic shock can be defined as an acute syndrome, and it is the most severe clinical manifestation of allergic diseases. Anaphylactoid reactions are similar to anaphylactic events but differ in the pathophysiological mechanism. Nitric oxide (NO) inhibitors during anaphylaxis suggest that NO might decrease the signs and symptoms of anaphylaxis but exacerbate associated vasodilation. Therefore, blocking the effects of NO on vascular smooth muscle by inhibiting the guanylate cyclase (GC) would be a reasonable strategy. This study aimed to investigate the effects of NO/cGMP pathway inhibitors methylene blue (MB), Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME), and indigo carmine (IC) in shock induced by compound 48/80 (C48/80) in rats. The effect was assessed by invasive blood pressure measurement. Shock was initiated by C48/80 intravenous bolus injection 5 min before (prophylactic) or after (treatment) the administration of the inhibitors MB (3 mg/kg), L-NAME (1 mg/kg), and IC (3 mg/kg). Of the groups that received drugs as prophylaxis for shock, only the IC group did not present the final systolic blood pressure (SBP) better than the C48/80 group. Regarding shock treatment with the drugs tested, all groups had the final SBP similar to the C48/80group. Altogether, our results suggested that inhibition of GC and NO synthase in NO production pathway was not sufficient to revert hypotension or significantly improve survival.
Asunto(s)
Animales , Masculino , Ratas , GMP Cíclico/antagonistas & inhibidores , Inhibidores Enzimáticos/administración & dosificación , Anafilaxia/tratamiento farmacológico , Músculo Liso Vascular/efectos de los fármacos , Óxido Nítrico/antagonistas & inhibidores , Ratas Wistar , NG-Nitroarginina Metil Éster/administración & dosificación , Modelos Animales de Enfermedad , Carmin de Índigo/administración & dosificación , Azul de Metileno/administración & dosificaciónRESUMEN
Os autores fazem uma revisäo atualizada sobre a neurocisticercose. Foram revisados os aspectos epidemiológicos, patológicos, as manifestaçöes clínicas, diagnóstico, tratamento, prognóstico e a profilaxia desta importante doença neurológica
Asunto(s)
Humanos , Cisticercosis , Cisticercosis/diagnóstico , Cisticercosis/etiología , Cisticercosis/terapia , Albendazol/uso terapéutico , Cisticercosis , Imagen por Resonancia Magnética , Praziquantel/uso terapéutico , Pronóstico , TomografíaRESUMEN
Se informa de 2 casos de micosis superficiales causados por Trichosporon beigelii, observados en personal militar y uno en un homosexual, en Sao Paulo, Brasil
Asunto(s)
Adulto , Humanos , Masculino , Enfermedades de los Genitales Masculinos/parasitología , Micosis/diagnóstico , Brasil , Cabello/parasitología , Trichosporon/aislamiento & purificaciónRESUMEN
Os autores analisam a prevalencia de dermatofitos em Juiz de Fora, Minas Gerais, atraves dos resultados de 3.513 exames micologicos. Chamam a atencao para o predominio de Trichophyton rubrum, T. mentagrophytes e Epidermophyton floccosum como os principais causadores de tinhas em nossa regiao, apesar da sua frequencia no solo desta cidade