RESUMEN
Se estudió el efecto de 2 compuestos de hemina obtenidos en el Centro de Química Farmacéutica: la hemina-arginina y el QF12, en el porcentaje de incorporación de 59 Fe a los eritrocitos circulantes de ratones normales. Se observó diferencia estadísticamente significativa entre todos los grupos al segundo día (p = 0,022). En las pruebas a posteriori, se encontró que el porcentaje de incorporación de 59 Fe promedio del grupo que recibió el QF12 a 6 mg/kg fue significativamente mayor que el que se obtuvo con el placebo (p = 0,021) y significativamente mayor que los encontrados con la hemina-arginina a 3 mg/kg (p = 0,021) y con la hemina-arginina a 6 mg/kg (p = 0,016), al segundo día después de la inyección del 59 Fe. La obtención del QF12, primer compuesto hemínico cubano, y el éxito obtenido en su primer ensayo preclínico, permitieron realizar la solicitud de su patente
Asunto(s)
Arginina , HeminaRESUMEN
Background. Since the discovery, several decades ago, of the infection of the gastric mucosa with Helicobacter pylory and its association with chronic antral gastritis and peptic ulcer, the treatment of ulcer illness has recently been revolutionized. Methods. In this study, the clinical effectiveness of three patients suffering from gastroduodenal peptic ulcer with helicobacter pylori were distributed randomly into three groups. Group I (n = 17) received 240 mg (CBS every 12 h for 6 weeks. Group II (n = 17) received 240 mg CBS every 8 h for 10 days. Group III (n = 19) received 240 mg CBS every 12 h for 6 weeks, plus metronidazole 500 mg every 8 h plus amoxicillin 750 mg every 12 h for 10 days. A duodenoscopy investigation with antrum biopsy for a morphologic study and detection of the germ was carried out by means of urease test and histological study (Warthin-Sarry and hematoxylin-eosin). Results. The three schemes of treat schemes of treatment were effective for ulcerous healing with 70.5 percent, 82.3 percent, and 78.2 percent, respectively, without significant differences. The highest clearing index (52.6 percent) was obtained in group III. Conclusions. With these treatment, the Helicobacter pylori eradication was only observed in 47.3 percent of the patients studied