RESUMEN
Introduction: Glioblastoma multiforme (GBM) is the most common malignant neoplasm of the central nervous system most frequently located in the supratentorial site and carries a grim prognosis. Case report: A 52 years old male patient presented with headache and vomiting since 3 months. In MRI T2W images showed peripheral hypointense rim with central heterogeneously hyper intense signals suggestive of high grade glioma. Patient was underwent neurosurgery and resected tumor was sent to histopathology department. Discussion: Grossly glioblastomas are relatively circumscribed and often appear to be more clearly demarcated from neighboring tissues. In our case microscopic examination showed presence of dense cellularity, striking pleomorphism, and zones of coagulative necrosis lined by ‘palisading’ tumor cells characterize the prototypical glioblastoma. Conclusion: As GBM carries poor prognosis and the treatment of malignant gliomas is still a challenge for us, further research on this disease is needed so that better treatments may be developed to improve the quality of life and prognosis of these patients.