RESUMEN
Background: Drug utilization studies (DUS) are used as potential tool in the evaluation of healthcare system. DUS are conducted to facilitate the rational use of drugs in populations. The indicators of prescription in practice measure the performance of health care provider in several key dimensions related to appropriate use of drug. Therefore, the present study was undertaken to analyze the prescription written by doctors in a Tertiary Care Hospital in rural area.Methods: Present study is a cross sectional, prospective and observational study. The study was conducted in a rural tertiary, teaching hospital at JIIU’s Indian Institute of Medical Science and Research, Warudi, Taluka Badnapur from January 2017 to September 2017 for duration of 9 months. Data was obtained from 300 prescriptions. Data was analysed as per WHO prescribing indicators.Results: Average number of drugs in the present study was found to be 2.85. Percentage of drugs prescribed by generic name is 13.48%. Percentage of encounters with an antibiotic prescribed 60%. Percentage of encounters with an injection prescribed 4.33%. Percentage of drugs prescribed from essential drugs list 72.91%.Conclusions: These types of studies help to design policy for rational use of drugs and motivation of physician for rational use of drugs.
RESUMEN
Background: According to WHO Pharmacovigilance is “The science and activities which are related to the detection, assessment, understanding, and the prevention of adverse effects or any other drug-related problems.” A majority of India’s population prefers government hospitals when they are in need of health care facilities. The patients also prefer other available free health care facilities. Hence, these hospitals can be a good source for generating an adverse drug reactions database. However, the Herculean task is to foster a culture of reporting among the doctors, especially among the junior doctors, as they are more closely associated with the patient care, hence the present study to assess awareness of pharmacovigilance among the doctors and to evaluate the impact of an educational intervention for improving awareness of pharmacovigilance among doctors in an Indian tertiary care teaching hospital. Methods: A suitable self-administered knowledge, attitude, practice (KAP) survey questionnaire was designed, based on previous studies. An interventional educational activity was organized and the impact of the educational Intervention was evaluated by again administering the similar questionnaire. The statistical analysis was carried for comparing the pre- and post-intervention. Results: It was seen that the KAP of pharmacovigilance among doctors is low. The results also showed that there was an improvement after the educational intervention. Conclusions: The KAP of pharmacovigilance is low among doctors and educational intervention can improve it.
RESUMEN
Background: Drug-induced hepatotoxicity is a potentially serious adverse effect of antituberculosis treatment (ATT) regimens containing isoniazid, rifampicin and pyrazinamide. Many in vitro and in vivo studies revealed that honey possess antioxidant property and hepotoprotective property but there is no systematic work available to test the effect of honey on antitubercular drugs induced hepatotoxicity in rats. Hence present study was carried out to explore the prophylactic and therapeutic effect of honey with its antioxidant activity against hepatotoxicity induced by antitubercular drugs (Isoniazid, Rifampicin and Pyrazinamide) in albino rats. Methods: Hepatotoxicity in rats treated with antitubercular drugs (Isoniazid, Rifampicin and Pyrazinamide) was studied by assessing parameters such as Serum alanine aminotransferase (ALT), Serum aspartate aminotransferase (AST), Serum total protein, Serum Malondialdehyde (MDA) and Serum Superoxide dismutase activity (SOD). The effect of Honey as co-administration and administration after establishment of hepatotoxicity on above parameter was investigated. These biochemical observations were supplemented by Histopathological examination of liver. Results: Honey significantly reversed changes in serum levels of AST, ALT, MDA, SOD, total protein and also histopathological changes produced by Antitubercular drugs. It was found that honey significantly prevented as well as reversed Antitubercular drugs induced hepatotoxicity and antioxidant activity. Conclusions: The results of present study show that honey has significant prophylactic and therapeutic value against antitubercular drugs induced hepatotoxicity.