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1.
International Journal of Arrhythmia ; : 1-2023.
Artículo en Inglés | WPRIM | ID: wpr-1000507

RESUMEN

Objective@#and methods To investigate the correlation between temperature and heart rate, we retrospectively reviewed 249 febrile patients with documented COVID-19 patients. RB was defined as a rise in the heart rate from a basal heart rate of less than 10 beats/minute/°C rise in temperature. @*Results@#In this study, the prevalence of RB in patients with COVID-19 was 60.6%. When the HR at peak temperatures for patients with COVID-19 was compared with reference valve (general temperature–heart rate response in infectious disease), our findings demonstrate a relatively lower heart rate at all peak temperatures recorded. Despite differences in heart rate response, there were not significant differences in clinical outcomes (pulmonary manifestation, intensive care unit admission, death). @*Conclusion@#Most patients with COVID-19 are associated with relative bradycardia, not related to clinical outcomes. RB in COVID-19 can be considered as the clinical features for differential diagnosis from other febrile conditions.

2.
Journal of Korean Medical Science ; : e297-2020.
Artículo | WPRIM | ID: wpr-831539

RESUMEN

Background@#There is limited information describing the presenting characteristics and dynamic clinical changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosed in the early phase of illness. This study is a case series of patients with coronavirus disease 2019 (COVID-19) admitted to 11 hospitals in Korea. @*Methods@#Patients with confirmed SARS-CoV-2 infection by positive polymerase chain reaction (PCR) testing of respiratory specimens by active surveillance that were finally discharged between February 20 and April 30, 2020 were included. Patients were classified into mild and non-mild groups on initial admission according to oxygen demand and Sequential Organ Failure Assessment score, and the mild group was followed up and subgrouped into non-aggravation and aggravation groups. @*Results@#A total of 161 patients with SARS-CoV2 infection were enrolled. Among the mild group of 136 patients, 11.7% of patients experienced clinical aggravation during hospitalization, but there was no initial clinical parameter on admission predicting their aggravation. Fever (odds ratio [OR], 4.56), thrombocytopenia (OR, 12.87), fever (OR, 27.22) and lactate dehydrogenase (LDH) > 300 U/L (OR, 18.35), and CRP > 1 mg/dL (OR, 11.31) significantly indicated aggravation in the 1st, 2nd, 3rd, and 4th 5-day periods, respectively.PCR positivity lasted for a median of 22 days and 32 days after the onset of illness in the nonaggravation and aggravation groups, respectively. @*Conclusion@#Old age was associated with early severe presentation. Clinical aggravation among asymptomatic or mild patients could not be predicted initially but was heralded by fever and several laboratory markers during the clinical course.

3.
Annals of Dermatology ; : 343-345, 2019.
Artículo en Inglés | WPRIM | ID: wpr-739371

RESUMEN

No abstract available.


Asunto(s)
Anciano , Femenino , Humanos , Dermoscopía , Diagnóstico
4.
Infection and Chemotherapy ; : 150-160, 2019.
Artículo en Inglés | WPRIM | ID: wpr-914578

RESUMEN

BACKGROUND@#Lamivudine and abacavir sulfate are widely used nucleoside/tide reverse transcriptase inhibitors (NRTI) backbone agents, which are recommended in major international treatment guidelines. The fixed-dose combination of lamivudine and abacavir sulfate has been developed to contribute to low pill burden of antiretroviral therapy (ART) regimen and patient adherence. A mandatory post-marketing surveillance was conducted in Korea to monitor the safety of Kivexa (lamivudine 300 mg/abacavir 600 mg).@*MATERIALS AND METHODS@#An open label, multi-center, non-interventional post-marketing surveillance was conducted to monitor the safety of Kivexa from July 2011 to July 2017 in 23 hospitals in Korea. Subjects over 12 years old taking Kivexa per prescribing information were enrolled. The primary outcome was defined as the occurrence of any adverse events during the study period. Secondary outcomes included the occurrence of adverse drug reaction, the occurrence of serious adverse events and the effectiveness of Kivexa.@*RESULTS@#A total of 600 patients from 23 hospitals were enrolled within the 6 years of study. The total observation period was 1,004 person-years. Three hundred and ten patients reported 674 adverse events. The incidence of upper respiratory infection (65 cases, 10.9%) was the highest, followed by diarrhea (20 cases, 3.3%), and nausea (18 cases, 3.0%). 109 subjects reported 71 events of adverse drug reactions, and the most common reaction was nausea in 2.33% of the subjects. Thirty-one subjects reported serious adverse events, none of them were considered drug related. From the total of 600 subjects, excluding 48 subjects who were ‘effectiveness unassessable’ by investigators, 552 patients were eligible for the subjective effectiveness analysis. 459 (83.2%) were evaluated as ‘improved’. Proportion of subjects whose human immunodeficiency virus-RNA is <50 copies/ml was 61.2% (309/505) at the beginning of observation and increased to 91.9% (464/505) at the end of study period.@*CONCLUSIONS@#The post-marketing surveillance showed the safety of Kivexa in HIV-1 patients in Korea. Ischemic cardiovascular events and hypersensitivity associated with Kivexa were few. There was no significant new safety information. This data may be helpful in implementing Kivexa and lamivudine/abacavir sulfate containing drugs in Korea.

5.
Journal of Korean Medical Science ; : e87-2019.
Artículo en Inglés | WPRIM | ID: wpr-764930

RESUMEN

We report 17 patients with human granulocytic anaplasmosis between January 2015 and September 2018 at two tertiary university hospitals in Korea. Monthly incidence peaked in May and June. Among these patients, we identified three who were co-infected with scrub typhus, and one patient with hemorrhagic fever with renal syndrome.


Asunto(s)
Animales , Humanos , Anaplasmosis , Coinfección , Fiebre Hemorrágica con Síndrome Renal , Hospitales Universitarios , Incidencia , Corea (Geográfico) , Tifus por Ácaros
6.
Journal of Korean Medical Science ; : e257-2019.
Artículo en Inglés | WPRIM | ID: wpr-765089

RESUMEN

BACKGROUND: Scrub typhus, severe fever with thrombocytopenia syndrome (SFTS) and human granulocytic anaplasmosis (HGA) are important arthropod-borne infectious diseases in Korea and share a common point that they are transmitted by arthropod bites mostly during outdoor activities and there are considerable overlaps of epidemiologic and clinical features at presentation. We investigated the co-infection of these infections. METHODS: The study subjects were patients with laboratory-confirmed scrub typhus who were enrolled retrospectively in 2006. SFTS virus (SFTSV) infection was confirmed by a reverse transcriptase polymerase chain reaction (PCR) to amplify partial L segment of SFTSV for molecular diagnosis. HGA was confirmed by a nested PCR to amplify 16S rRNA gene of Anaplasma phagocytophilum. Direct sequencing of the positive PCR products was performed. Clinical features of co-infected subjects were described. RESULTS: One-hundred sixty-seven patients with scrub typhus were included in the analysis. Co-infection of A. phagocytophilum was identified in 4.2% of scrub typhus patients (7/167). The route of co-infection was uncertain. The co-infected patients had not different clinical manifestations compared to the patients with scrub typhus only. All the study subjects were negative for SFTSV. CONCLUSION: We found retrospective molecular evidence of the co-infection of scrub typhus and HGA in Korea. HGA may be more prevalent than expected and need to be considered as an important differential diagnosis of febrile patients in Korea.


Asunto(s)
Animales , Humanos , Anaplasma phagocytophilum , Anaplasmosis , Artrópodos , Coinfección , Enfermedades Transmisibles , Diagnóstico , Diagnóstico Diferencial , Fiebre , Genes de ARNr , Corea (Geográfico) , Reacción en Cadena de la Polimerasa , Estudios Retrospectivos , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Tifus por Ácaros , Trombocitopenia
7.
Journal of Korean Medical Science ; : e262-2018.
Artículo en Inglés | WPRIM | ID: wpr-717604

RESUMEN

Pathogenic gram-negatives that produce 16S ribosomal RNA methyltransferases (16S RMTases) have already been distributed all over the world. To investigate the predominance of aminoglycoside resistance associated with 16S RMTases in Korea, we collected a total of 222 amikacin resistant Gram-negative clinical isolates from patient specimens between 1999 and 2015 from three hospital banks across Korea. ArmA and rmtB were the predominant 16S RMTase genes responsible for aminoglycoside-resistant isolates circulating in Korean community settings although only one rmtA-producing isolate was detected in 2006.


Asunto(s)
Humanos , Amicacina , Corea (Geográfico) , Metiltransferasas , ARN Ribosómico 16S
8.
Korean Journal of Dermatology ; : 88-89, 2018.
Artículo en Inglés | WPRIM | ID: wpr-738813

RESUMEN

No abstract available.


Asunto(s)
Chancro , Homosexualidad
9.
Infection and Chemotherapy ; : 51-54, 2018.
Artículo en Inglés | WPRIM | ID: wpr-721500

RESUMEN

Non-Hodgkin's lymphoma of B-cell type is the second most common neoplasm after Kaposi's sarcoma among patients with human immunodeficiency virus infection. Most non-Hodgkin's lymphoma cases that are associated with acquired immunodeficiency syndrome (AIDS) involve extranodal sites, especially the digestive tract and the central nervous system. We report a case of multiple jejunal intussusception caused by Burkitt lymphoma in a 42-year-old AIDS patient. Upper gastrointestinal endoscopy and surgical biopsy were performed and a complete diagnostic study including histological and immunohistochemical analyses showed Burkitt lymphoma.


Asunto(s)
Adulto , Humanos , Síndrome de Inmunodeficiencia Adquirida , Linfocitos B , Biopsia , Linfoma de Burkitt , Sistema Nervioso Central , Endoscopía Gastrointestinal , Tracto Gastrointestinal , VIH , Intususcepción , Linfoma no Hodgkin , Sarcoma de Kaposi
10.
Infection and Chemotherapy ; : 51-54, 2018.
Artículo en Inglés | WPRIM | ID: wpr-722005

RESUMEN

Non-Hodgkin's lymphoma of B-cell type is the second most common neoplasm after Kaposi's sarcoma among patients with human immunodeficiency virus infection. Most non-Hodgkin's lymphoma cases that are associated with acquired immunodeficiency syndrome (AIDS) involve extranodal sites, especially the digestive tract and the central nervous system. We report a case of multiple jejunal intussusception caused by Burkitt lymphoma in a 42-year-old AIDS patient. Upper gastrointestinal endoscopy and surgical biopsy were performed and a complete diagnostic study including histological and immunohistochemical analyses showed Burkitt lymphoma.


Asunto(s)
Adulto , Humanos , Síndrome de Inmunodeficiencia Adquirida , Linfocitos B , Biopsia , Linfoma de Burkitt , Sistema Nervioso Central , Endoscopía Gastrointestinal , Tracto Gastrointestinal , VIH , Intususcepción , Linfoma no Hodgkin , Sarcoma de Kaposi
11.
Yonsei Medical Journal ; : 259-260, 2017.
Artículo en Inglés | WPRIM | ID: wpr-126247

RESUMEN

No abstract available.

12.
The Korean Journal of Internal Medicine ; : 761-763, 2017.
Artículo en Inglés | WPRIM | ID: wpr-67777

RESUMEN

No abstract available.


Asunto(s)
Humanos , Escherichia coli , Tifus por Ácaros
13.
Infection and Chemotherapy ; : 205-212, 2017.
Artículo en Inglés | WPRIM | ID: wpr-201458

RESUMEN

BACKGROUND: Abacavir is a widely-used nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus (HIV) infection. Mandatory postmarketing surveillance was conducted in Korea to monitor the safety and evaluate the effectiveness of Ziagen® (abacavir sulfate 300 mg; ViiV Healthcare, Middlesex, UK). MATERIALS AND METHODS: An open-label, multi-center, non-interventional postmarketing surveillance study was conducted from June 2010 to June 2016 to monitor the safety and effectiveness of Ziagen across 12 hospitals in Korea. Subjects older than 18 years taking Ziagen according to prescribing information were enrolled. The primary outcome was defined as the occurrence of any adverse events after Ziagen administration. Secondary outcomes included the occurrence of adverse drug reactions, occurrence of serious adverse events, and effectiveness of Ziagen administration. RESULTS: A total of 669 patients were enrolled in this study, with a total observation period of 1047.8 person-years. Of these, 90.7% of patients were male. The mean age of patients was 45.8±11.9 years. One-hundred ninety-six (29.3%) patients reported 315 adverse events, and four patients reported seven serious adverse events, without any fatal events. There was one potential case of an abacavir hypersensitivity reaction. Among the 97 adverse drug reactions that were reported from 75 patients, the most frequent adverse drug reactions included diarrhea (12 events), dyspepsia (10 events), and rash (9 events). No ischemic heart disease was observed. In the effectiveness analysis, 91% of patients achieved HIV-1 RNA under 50 copies/mL after 24 months of observation with abacavir administration. CONCLUSION: Our data showed the safety and effectiveness of Ziagen in a real-world setting. During the study period, Ziagen was well-tolerated, with one incident of a clinically suspected abacavir hypersensitivity reaction. The postmarketing surveillance of Ziagen did not highlight any new safety information. These data may be helpful in understanding abacavir and the HIV treatment practices in Korea.


Asunto(s)
Humanos , Masculino , Atención a la Salud , Diarrea , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Dispepsia , Exantema , VIH , VIH-1 , Hipersensibilidad , Corea (Geográfico) , Isquemia Miocárdica , Farmacoepidemiología , ARN , ADN Polimerasa Dirigida por ARN
14.
Infection and Chemotherapy ; : 118-126, 2016.
Artículo en Inglés | WPRIM | ID: wpr-51105

RESUMEN

BACKGROUND: From May to July 2015, the Republic of Korea experienced the largest outbreak of Middle East respiratory syndrome (MERS) outside the Arabian Peninsula. A total of 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as of September 30th, 2015. MATERIALS AND METHODS: We obtained information of patients who were confirmed to have MERS-CoV infection. MERS-CoV infection was diagnosed using real-time reverse-transcriptase polymerase chain reaction assay. RESULTS: The median age of the patients was 55 years (range, 16 to 86). A total of 55.4% of the patients had one or more coexisting medical conditions. The most common symptom was fever (95.2%). At admission, leukopenia (42.6%), thrombocytopenia (46.6%), and elevation of aspartate aminotransferase (42.7%) were observed. Pneumonia was detected in 68.3% of patients at admission and developed in 80.8% during the disease course. Antiviral agents were used for 74.7% of patients. Mechanical ventilation, extracorporeal membrane oxygenation, and convalescent serum were employed for 24.5%, 7.1%, and 3.8% of patients, respectively. Older age, presence of coexisting medical conditions including diabetes or chronic lung disease, presence of dyspnea, hypotension, and leukocytosis at admission, and the use of mechanical ventilation were revealed to be independent predictors of death. CONCLUSION: The clinical features of MERS-CoV infection in the Republic of Korea were similar to those of previous outbreaks in the Middle East. However, the overall mortality rate (20.4%) was lower than that in previous reports. Enhanced surveillance and active management of patients during the outbreak may have resulted in improved outcomes.


Asunto(s)
Humanos , Antivirales , Aspartato Aminotransferasas , Infecciones por Coronavirus , Brotes de Enfermedades , Disnea , Oxigenación por Membrana Extracorpórea , Fiebre , Hipotensión , Leucocitosis , Leucopenia , Enfermedades Pulmonares , Coronavirus del Síndrome Respiratorio de Oriente Medio , Medio Oriente , Mortalidad , Neumonía , Reacción en Cadena de la Polimerasa , República de Corea , Respiración Artificial , Trombocitopenia
15.
Infection and Chemotherapy ; : 246-248, 2016.
Artículo en Inglés | WPRIM | ID: wpr-28861

RESUMEN

No abstract available.


Asunto(s)
Enterobacteriaceae , Corea (Geográfico)
16.
Infection and Chemotherapy ; : 1-11, 2016.
Artículo en Inglés | WPRIM | ID: wpr-70885

RESUMEN

Arbekacin is a broad-spectrum aminoglycoside used to treat methicillin-resistant Staphylococcus aureus (MRSA). Arbekacin has antibacterial activities against high-level gentamicin-resistant Enterococci, multidrug-resistant Pseudomonas aeruginosa, and Acinetobacter baumannii et al. Here, we reviewed in vitro data on arbekacin in Staphylococci and Gram-negative microorganisms. We also reviewed clinical studies for clinical efficacy and microbiologic efficacy data in patients with identified MRSA and suspected MRSA infections. The overall clinical efficacy ranged from 66.7% to 89.7%. The microbiologic efficacy rate ranged from 46.2% to 83%. In comparative studies between arbekacin and glycopeptides, arbekacin was similar to other glycopeptides with respect to clinical and microbiological efficacy rates. Combination trials with other antibiotics suggest that arbekacin will be a promising strategy to control Enterococcus spp. multi-drug resistant P. aeruginosa. The major adverse reaction was nephrotoxicity/hepatotoxicity, but patients recovered from most adverse reactions without any severe complications. Based on these results, arbekacin could be a good alternative to vancomycin/teicoplanin in MRSA treatment. Finally, therapeutic drug monitoring is recommended to maximize clinical efficacy and decrease nephrotoxicity.


Asunto(s)
Humanos , Acinetobacter baumannii , Antibacterianos , Monitoreo de Drogas , Enterococcus , Glicopéptidos , Staphylococcus aureus Resistente a Meticilina , Pseudomonas aeruginosa
17.
Yonsei Medical Journal ; : 1047-1048, 2016.
Artículo en Inglés | WPRIM | ID: wpr-194117

RESUMEN

No abstract available.

18.
Journal of Korean Medical Science ; : 1698-1700, 2015.
Artículo en Inglés | WPRIM | ID: wpr-198117

RESUMEN

Acute cholecystitis is a rare complication of scrub typhus. Although a few such cases have been reported in patients with scrub typhus, the clinical course is not well described. Of 12 patients, acute cholecystitis developed in 66.7% (8/12) of patients older than 60 yr. The scrub typhus group with acute cholecystitis had marginal significant longer hospital stay and higher cost than the group without cholecystitis according to propensity score matching. Scrub typhus should be kept in mind as a rare etiology of acute cholecystitis in endemic areas because the typical signs of scrub typhus such as skin rash and eschar can present after the abdominal pain.


Asunto(s)
Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Colecistitis Aguda/diagnóstico , Diagnóstico Diferencial , República de Corea , Tifus por Ácaros/complicaciones , Resultado del Tratamiento
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