High Prevalence of Ceftazidime-Resistant Klebsiella pneumoniae and Increase of Imipenem-Resistant Pseudomonas aeruginosa and Acinetobacter spp. in Korea: a KONSAR Program in 2004

A nationwide antimicrobial resistance surveillance has been conducted since 1997 in Korea. In this study, susceptibility test data generated in 2004 by KONSAR group hospitals were analyzed and compared to those at a commercial laboratory. In hospitals, the rank orders of organisms in 2004 were identical to those in 2003. The most prevalent species was Staphylococcus aureus (20.2%) in hospitals, but Escherichia coli (29.7%) in the commercial laboratory. The proportions of Enterococcus faecium to all isolates of Enterococcus faecalis plus E. faecium were 47.2% in hospitals and 24.9% in the commercial laboratory. The mean resistance rates of significant antimicrobial-organism combinations in hospitals were: oxacillin-resistant S. aureus (68%), oxacillin-resistant (penicillin- nonsusceptible) Streptococcus pneumoniae (68%), vancomycin-resistant E. faecium (25%), cefotaxime-resistant E. coli (14%), ceftazidime- and cefoxitin-resistant Klebsiella pneumoniae (34% and 32%, respectively), and imipenem-resistant Acinetobacter spp. and Pseudomonas aeruginosa (17% and 24%, respectively). In conclusion, oxacillin-resistant staphylococci, expanded-spectrum cephalosporin-resistant K. pneumoniae, and imipenem-resistant Acinetobacter spp. and P. aeruginosa were prevalent in 2004. Increasing trends were observed for vancomycin-resistant E. faecium, cefoxitin- resistant E. coli and K. pneumoniae, and imipenem-resistant Acinetobacter spp. and P. aeruginosa. Certain antimicrobial- organism combinations were also prevalent among the commercial laboratory-tested strains.

A Case of DeMorsier Syndrome Misdiagnosed as Amblyopia

PURPOSE: We report a 32-year-old man with DeMorsier syndrome, who was referred for seizures, esotropia and visual disturbance of left eye. METHODS: Fundus examination, visual field examination and the visual evoked potential were performed, and other diagnostic studies included endocrine determinations, the electroencephalogram and MR imaging. RESULTS: Ophthalmic examination revealed left optic nerve hypoplasia with the "double ring" sign. Axial MR T1 weighted image showed tiny left optic nerve and absence of the septum pellucidum. Subsequent evaluation revealed temporal visual field defect, abnormal VEP and deuteranomaly of left eye.

Keratitis in Measles

PURPOSE: To determine the natural history and clinical characteristics of keratitis associated with measles which is currently epidemic in Korea. METHODS: Eighty-four hospitalized patients with measles were prospectively examined between December 2000 and March 2001, during their admission period. Ocular and adnexal examination was performed with a slit lamp biomicroscope. Fundus examination and corneal sensitivity test were also performed. RESULTS: The age and sex distributions were not significant. Age of patients ranged from 18 months to 19 years. All patients with measles have conjunctivitis signs, such as follicles and injection. Superficial keratitis was detected in 7 of 84 patients (8.3%). Corneal lesions were bilateral, well demarcated, round, multiple and 0.2 to 0.4 mm in size. The mean duration of keratitis was 10.1+/-2.9 days in this study. All keratitis resolved spontaneously using artificial tears and prophylactic antibiotic eyedrops CONCLUSIONS:Keratitis associated with measles developed frequently (8.3%), so careful ophthalmic examination should be performed in measles.