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1.
Acta Physiologica Sinica ; (6): 831-839, 2007.
Artículo en Chino | WPRIM | ID: wpr-316774

RESUMEN

To test the hypothesis that concentration polarization of atherogenic lipids may occur in the arterial system and play an important role in localization of atherosclerosis, we simulated and measured in vitro the luminal surface concentration of low density lipoprotein (LDL) in local stenosis at the distal end of carotid artery by number simulation and laser scanning confocal microscopy, then we designed carotid stenosis model to test the role of LDL concentration polarization in atherogenesis. The in vitro experiment showed that the luminal surface LDL concentration was higher than the bulk concentration as predicted by the concentration polarization theory. The relative luminal surface LDL concentration changed with the flow velocity and ratio of stenosis. The wall concentration of LDL was highest in the round tube with 40% stenosis at the same velocity, while the wall concentration of LDL was higher when Re was 250 than Re was 500 at the same extent of narrowness. The animal experiment also revealed that general atherogenic plaques obviously occurred at the distal end of local stenosis where concentration polarized. The results strongly support our hypothesis that concentration polarization of lipoproteins occurs in local stenosis at the distal end of carotid artery, and this in turn promotes the localization of atherosclerosis which develops in the arterial system.


Asunto(s)
Animales , Aterosclerosis , Estenosis Carotídea , Modelos Animales de Enfermedad , Lipoproteínas LDL , Metabolismo
2.
Chinese Journal of Medical Instrumentation ; (6): 439-442, 2005.
Artículo en Chino | WPRIM | ID: wpr-232913

RESUMEN

This review is a summary of some useful methods and advances about improving clinical applications to small-diameter vascular grafts in recent years, and it points out the developing orientation of small-diameter vascular grafts in the future.


Asunto(s)
Órganos Bioartificiales , Células Endoteliales , Endotelio Vascular , Ingeniería de Tejidos , Injerto Vascular
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