Abnromal expression of p53,IGF-IR and PCNA in benign and malignant breast lesions of Han,Uygur woman in Xinjiang / 中国癌症杂志

Purpose:Detection of p53,IGF IR and PCNA abnormal expression in tumor tissues of Han, Uygur patients with breast benign and malignant lesions may offer more important molecular biologic data of human breast carcinogenesis. Methods:p53?IGF IR and PCNA in 56 breast cancer,38 adenosis, 25 papilloma tissues were dectected by immunohistochemistry (LSAB). Results:The postive frequency of p53 protein, PCNA in breast cancer (58 9%, 98.2%) was found to be notably higher than in benign lesions (4%～5.3%,76%～78.9%) respectively ( P