Regulation of signaling pathways associated with cardiac valve development / 国际儿科学杂志

Congenital heart disease is the most common birth defect in China, of which heart valve dysplasia is an important phenotype.Heart valve development is an important process of embryonic development, which is regulated by a variety of signaling pathways.If the process of proliferation, differentiation or migration of endothelial cells and cardiomyocytes is abnormal, the heart valve will develop abnormally and the valvular heart disease may occur.Tissue explant systems and various animal model experiments have demonstrated that multiple signaling pathways interact to form a vast regulatory network that collectively regulates the development of heart valves.This review will highlight the nost intensively studied signaling pathways in epithelial-mesenchymal transition, including VEGF, NFATc1, Notch, Wnt, TGF-β, ErbB, and NF1 signaling pathways.

The treatment and long-term management of severe coronary artery lesion in Kawasaki disease / 中国小儿急救医学

Giant coronary aneurysm is the most severe complication of Kawasaki disease and is the leading cause of cardiovascualr events, which can cause coronary artery stenosis, thromboembolism, myocardial ischemia and even death.We aim to improve the prognosis of the patients with sever coronary artery lesions by comprehensive management including active anti-inflammatory and antithrombotic therapy in acute and subacute phase, as well as optimal treatment and follow-up plan according to morphologic evaluation of coronary artery lesions and myocardial ischemia after convalescent period.

Regulation of signaling pathways associated with cardiac valve development / 国际儿科学杂志

Congenital heart disease is the most common birth defect in China,of which heart valve dysplasia is an important phenotype.Heart valve development is an important process of embryonic development,which is regulated by a variety of signaling pathways.If the process of proliferation,differentiation or migration of endothelial cells and cardiomyocytes is abnormal,the heart valve will develop abnormally and the valvular heart disease may occur.Tissue explant systems and various animal model experiments have demonstrated that multiple signaling pathways interact to form a vast regulatory network that collectively regulates the development of heart valves.This review will highlight the nost intensively studied signaling pathways in epithelial-mesenchymal transition,including VEGF,NFATc1,Notch,Wnt,TGF-β,ErbB,and NF1 signaling pathways.