Novel 4-hydroxy-N'-[(1E)-substituted-phenylmethylidene] benzohydrazide analogs (hydrazones) as potent antibacterial and anti-oxidant agents

In the present study, a series of 4-hydroxy-Nʹ-[(1E)-substituted-phenylmethylidene] benzohydrazide analogs was synthesized, characterized, and evaluated for their antibacterial and anti-oxidant activity. All the tested compounds show high antibacterial activity with compound AR7 , Nʹ-(3,4,5-trimethoxybenzylidene)-4-hydroxybenzohydrazide as the most active compound, whereas compounds AR10 (hydrogen peroxide scavenging) and AR8 (2,2-diphenyl-1- picrylhydrazyl radical scavenging activity method) were found to possess maximum anti-oxidant activity indicating that different mechanisms are involved in different anti-oxidant determination methods.